CDC20 - cell division cycle 20 Gene

Also Known as CDC20A; p55CDC; bA276H19.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 991

About CDC20

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:43,358,981-43,363,203 (from NCBI)

This gene has 4 transcripts (splice variants), 220 orthologues and 2 paralogues. Biased expression in testis (RPKM 26.5), bone marrow (RPKM 19.7) and 12 other tissues.

Summary

CDC20 appears to act as a regulatory protein interacting with several Other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]

CDC20 Products (1)

mRNA Protein Name
NM_001255.3 NP_001246.2 cell division cycle protein 20 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables anaphase-promoting complex binding IDA
IDA: Inferred from direct assay
14743218 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10700282 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
27030811 GOA
Biological Process GO Annotation Evidence References Source
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: Inferred from direct assay
17443180 GOA
involved in metaphase/anaphase transition of meiosis I IMP
IMP: Inferred from mutant phenotype
32666501 GOA
involved in positive regulation of mitotic metaphase/anaphase transition IDA
IDA: Inferred from direct assay
9637688 GOA
involved in positive regulation of ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
11459826 GOA
Cellular Component GO Annotation Evidence References Source
part of anaphase-promoting complex IDA
IDA: Inferred from direct assay
11459825 GOA
part of mitotic checkpoint complex IPI
IPI: Inferred from physical interaction
27509861 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC20 Protein Structure

WD40

WD40: WD domain, G-beta repeat (302 - 336)

WD40

WD40: WD domain, G-beta repeat (345 - 386)

WD40

WD40: WD domain, G-beta repeat (436 - 470)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 499 a.a.
Protein Preferred Names Protein Names

cell division cycle protein 20 homolog

  • CDC20 cell division cycle 20 homolog

CDC20 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CDC20 Q12834 ANAPC4 Homo sapiens Q9UJX5
Anti Bait CoIP
25383541
Intra
CDC20 Q12834 ANAPC4 Homo sapiens Q9UJX5
TAP
20360068
Intra
CDC20 Q12834 ANAPC4 Homo sapiens Q9UJX5
Anti Tag CoIP
25383541
Intra
CDC20 Q12834 RASSF1 Homo sapiens Q9NS23-2
CoIP
14743218
Cross
CDC20 Q12834 Axin2 Mus musculus O88566
Anti Tag CoIP
22322943
Intra
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
15182668
Intra
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
21407176
Intra
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
22340593
Intra
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
24581499
Intra
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
37926298
Intra
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Pull Down
18022367
Intra
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Tag CoIP
25383541
Intra
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
TAP
20360068
Intra
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Tag CoIP
33961781
Intra
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
20212161
Intra
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Pull Down
17443186
Intra
CDC20 Q12834 CDC27 Homo sapiens P30260
TAP
20360068
Intra
CDC20 Q12834 CDC27 Homo sapiens P30260
Anti Bait CoIP
17443186
Intra
CDC20 Q12834 CDC27 Homo sapiens P30260
Anti Bait CoIP
24781523
Intra
CDC20 Q12834 CDC27 Homo sapiens P30260
Anti Tag CoIP
22014574
Cross: Cross-species interaction Intra: Intraspecies interaction

CDC20 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810856 CDC20 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P89872 Cdc20 Antibody (YA9216) WB, ICC/IF, IF-Tissue, IP human

Related Diseases

Diseases Alias
Mosaic Variegated Aneuploidy Syndrome 1

  • Mva Syndrome

  • MVA1

  • Mosaic Variegated Aneuploidy Syndrome, Type 1

  • Mosaic Variegated Aneuploidy Syndrome

  • Congenital Chromosomal Disease
Mosaic Variegated Aneuploidy Syndrome

  • Warburton-Anyane-Yeboa Syndrome

  • Mva Syndrome

  • Mosaic Variegated Aneuplody Microcephaly Syndrome

  • Warburton Anyane Yeboa Syndrome
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110287 Apcin 99.62% Unkown
HY-130257 CP5V 99.31% Unkown
HY-13255 TAME Inhibitor 99.51% Unkown
HY-100341 M2I-1 Inhibitor 98.0% Unkown
HY-130841 Apcin-A Inhibitor 98.0% Unkown
HY-13255A TAME hydrochloride Inhibitor 98.31% Unkown
HY-116006 Bis-PEG5-acid 99.90% Unkown
HY-131959 (S,R,S)-AHPC-PEG5-Boc / Unkown
HY-RS02288 CDC20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-161257 CDC20-IN-1 Inducer / Unkown
HY-172401 CDC20-IN-2 / Unkown
HY-179012 CDC20/HSP90-IN-1 / Unkown
HY-RS02289 CDC20B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181030 BDE30671203 / Unkown
HY-RS16827 Cdc20 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23269 Cdc20 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W614725 Apcin-A monohydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CDC20 VGNC VGNC:107502
Rattus norvegicus CDC20 RGD RGD:620477
Mus musculus CDC20 MGD MGI:1859866
Bos taurus CDC20 VGNC VGNC:27060
Canis familiaris CDC20 VGNC VGNC:38987
Others CDC20 NCBI