GY1-22
GY1-22 is an inhibitor of DNAJA1-mutP53R175H interacting pocket. GY1-22 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 326903-84-8
- Formula: C23H20N4OS
- Molecular Weight:400.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
DNAJA1-mutP53R175H interacting pocket[1]
GY1-22 (0-50 μM; 24 h) reduces mutp53 protein expression in mouse pancreatic cancer P03 and human colon cancer LS123 cells. GY1-22 inhibits cyclin D1 expression and induces wtp53-activated Waf1p21 expression in mutp53-driven P03 cells[1].
GY1-22 loses the ability to degrade mutp53R175H after mutation of critical sites at the interface of the DNAJA1–mutp53R175H complex[1].
GY1-22 (0-100 μM; 24 h) shows a dose-dependent effect on inhibiting cell growth and low cytotoxicity in mutp53-driven P03 pancreatic cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse mutp53-driven P03 pancreatic cancer cells and human colon cancer LS123 cells
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Concentration:0, 1, 10, 25 and 50 μM
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Incubation Time:24 h
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Result:Reduced mutp53 protein expression in both cells.
Exhibited a dose-dependent effect on inhibition of mutp53 and cyclin D1 expression but induction of wtp53-activated Waf1p21 expression tested in P03 cells.
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Cell Line:Mouse mutp53-driven P03 pancreatic cancer cells
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Concentration:0, 25, 50, 75 and 100 μM
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Incubation Time:24 h
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Result:Showed a dose-dependent effect on inhibiting cell growth with IC50 of 28 μM and low cytotoxicity (cell viability).
GY1-22 (1 mg/kg; i.p.; daily for 2 weeks) inhibits mutp53-driven P03 pancreatic cancer cell growth in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice implanted with P03 cells[1]
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Dosage:1 mg/kg
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Administration:IP, daily for 2 weeks
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Result:Showed a significant inhibition of in vivo tumor growth, which was comparable with P03 DNAJA1 knockout line.
Chemical Information
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CAS No. 326903-84-8
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Molecular Weight 400.50
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Formula C23H20N4OS
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SMILES
C1(N=C(SCC2=NC3=C(N2)C=CC=C3)N4CCOC5=CC=CC=C5)=C4C=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GY1-22 Related Classifications
HY-149911 Related Classifications
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