Remacemide hydrochloride
Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively. Remacemide hydrochloride is an anticonvulsant agent.
For research use only. We do not sell to patients.
- CAS No.: 111686-79-4
- Formula: C17H21ClN2O
- Molecular Weight:304.81
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
-
HY-B1776A
Spermidine hydrochlorideAntioxidant Agent -
HY-100834
5,7-Dichlorokynurenic acidNMDA Receptor Antagonist -
HY-13457
TCN 201NMDA Receptor Antagonist -
HY-100797
(RS)-CPPNMDA Antagonist -
HY-B1776AR
Spermidine hydrochloride (Standard)Antioxidant Agent -
HY-15084A
(-)-Dizocilpine maleateNMDA Receptor Antagonist -
HY-100814
(R)-CPPNMDA Receptor Inhibitor -
HY-107711
DQP-1105GluN1/GluN2C Antagonist -
HY-30006
1-Aminocyclobutanecarboxylic acidCyclobutane-type Amino Acid -
HY-15086
SelfotelNMDA Antagonist -
HY-100920
Arcaine sulfateNMDA Receptor Antagonist -
HY-101178
L-689560NMDA Antagonist
All iGluR Isoforms
More
Biological Activity
Description
IC50 & Target
IC50: 68-76 μM (NMDA receptor)[1]
IC50:160.6 μM(sodium channel)[2]
In Vitro
Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na+ channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC50 value of 160.6 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female Sprague–Dawley rats ( 190-210 g )[3]
-
Dosage:100 mg/kg and 150 mg/kg
-
Administration:Orogastric gavage; once a day; 7 days
-
Result:Increased the number of sessions required to complete audio/visual discrimination (AVD) training.
Chemical Information
-
CAS No. 111686-79-4
-
Molecular Weight 304.81
-
Formula C17H21ClN2O
-
SMILES
NCC(NC(C)(C1=CC=CC=C1)CC2=CC=CC=C2)=O.[H]Cl
-
Synonyms
FPL 12924AA
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. G C Palmer, et al. Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann N Y Acad Sci. 1995 Sep 15;765:236-47; discussion 248. [Content Brief]
[2]. Sarah Santangeli, et al. Na+ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur J Pharmacol. 2002 Mar 1;438(1-2):63-8. [Content Brief]
[3]. L K M Wright, et al. Behavioral effects associated with chronic ketamine or remacemide exposure in rats. Neurotoxicol Teratol. May-Jun 2007;29(3):348-59. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Remacemide hydrochloride Related Classifications
HY-107695 Related Classifications
Powered by Bioz