SR-16434
SR-16434 is a nociceptin/orphanin FQ (NOP)/μ-opioid receptor partial agonist, with high binding affinity (NOP receptor Ki=7.49; μ-Opioid receptor Ki=2.70). SR-16434 can relieve pain.
For research use only. We do not sell to patients.
- CAS No.: 857262-16-9
- Formula: C22H30N2O
- Molecular Weight:338.49
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Opioid Receptor Isoforms
More
Biological Activity
|
NOP receptor 7.49 (Ki) |
μ-opioid 2.70 (Ki) |
κ-opioid 219.47 (Ki) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
28.7 nM
Compound: 2
|
Agonist activity at human nociceptin receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis
Agonist activity at human nociceptin receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis
|
[PMID: 23623415] |
| CHO | EC50 |
29 nM
Compound: 2
|
Agonist activity at human mu opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis
Agonist activity at human mu opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis
|
[PMID: 23623415] |
| CHO | EC50 |
<10000 nM
Compound: 2
|
Agonist activity at human kappa opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis
Agonist activity at human kappa opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis
|
[PMID: 23623415] |
SR 16434 (10, 30 mg/kg; s.c. once daily for 9 days) produces an increase in tail-lick latency across days, induces conditioned place preference, and decreases global activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:20 to 25 g male ICR mice[1]
-
Dosage:10, 30 mg/kg
-
Administration:s.c. for single-dose
-
Result:Produced dose-dependent increase in tail-flick latency and induced antinociception.
-
Animal Model:20 to 25 g male ICR mice[1]
-
Dosage:10, 30 mg/kg
-
Administration:s.c. once daily for 9 days
-
Result:Produced an increase in tail-lick latency across days, induced conditioned place preference, and decreased global activity.
Chemical Information
-
CAS No. 857262-16-9
-
Molecular Weight 338.49
-
Formula C22H30N2O
-
SMILES
O=C1N(C2CCN(C3C4CCCC3CCC4)CC2)C5=C(C=CC=C5)C1
-
Synonyms
SR-16435 free base
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SR-16434 Related Classifications
HY-122681 Related Classifications
Powered by Bioz