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Cat. No.: HY-P2074

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U 77436

U 77436 is a Renin inhibitory peptide. U 77436 is used in the research of hypertension.

For research use only. We do not sell to patients.

CAS No.: 128657-36-3
Formula: C₅₀H₇₆N₁₀O₁₁
Molecular Weight:993.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

U 77436 Chemical Structure

CAS No.: 128657-36-3

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

U 77436 is a Renin inhibitory peptide. U 77436 is used in the research of hypertension^[1].

In Vivo

U 77436 (25 μg/rat; intratracheal administration) achieves an absorption rate of 52.1% in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley (male, 400-550 g)^[1]
Dosage:

25 μg/rat (intrapulmonary); 75 μg/rat (intravenous)
Administration:

intrapulmonary; single dose; intravenous; single dose
Result:

Achieved total recovery of 104.9% in bile and urine after intravenous administration, with 93.3% recovered in bile and 11.6% recovered in urine.
Achieved total recovery of 53.7% in bile and urine after intrapulmonary administration, with 48.0% recovered in bile and 5.7% recovered in urine.
Reached 52.1% intrapulmonary absorption relative to intravenous recovery.
Showed 63% of ⁵¹Cr-labeled dose reached the lungs, with an estimated 81% of the lung-delivered dose absorbed by 10 hours.

Chemical Information

CAS No. 128657-36-3
Molecular Weight 993.20
Formula C₅₀H₇₆N₁₀O₁₁
SMILES

[O-][N+]1=CC=CC=C1CNC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)C[C@H](O)[C@H](CC(C)C)NC([C@H](CC2=CN=CN2)N(C)C([C@H](CC3=CC=CC=C3)NC([C@H]4N(CCC4)C(NC(CO)(CO)CO)=O)=O)=O)=O)=O)=O
Sequence

{Pro(NHCO-NH-C(CH2OH)3)}-Phe-{His(NCH3)}-Leu{(CHOH-CH2)}-Val-{Ile(NHCH2-C5H4NO)}
Sequence Shortening

{Pro(NHCO‑NH‑C(CH2OH)3)}‑F‑{His(NCH3)}-Leu{(CHOH‑CH2)}-V-{Ile(NHCH2-C5H4NO)}
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sheehy AM, et al. Intrapulmonary delivery of renin inhibitory peptides results in sustained release because of saturable transport. Pharm Res. 1993 Oct;10(10):1548-51. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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