13′-Hydroxy-δ-tocopherol
13′-Hydroxy-δ-tocopherol is a metabolite of long-chain vitamin E. 13′-Hydroxy-δ-tocopherol can induces cells apoptosis and minor reduction in mitochondrial membrane potential. 13′-Hydroxy-δ-tocopherol can be used for the research of hepatocellular carcinoma.
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- CAS No.: 1308347-24-1
- Formule: C27H46O3
- Masse moléculaire:418.65
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
13′-Hydroxy-δ-tocopherol (Compound δ-13′-OH) (24 h) exhibits weak antiproliferative activity in HepG2 cells, with an EC50 >50 μM[1].
13′-Hydroxy-δ-tocopherol (20 μM; 6 h) induces significant apoptotic cell death in HepG2 cells, inducing cleavage of caspase-3, caspase-7, caspase-9, and PARP-1[1].
13′-Hydroxy-δ-tocopherol (10 μM; 6 h) does not significantly induce intracellular or intramitochondrial ROS formation in HepG2 cells[1].
13′-Hydroxy-δ-tocopherol (20 μM; 1 h) significantly reduces mitochondrial membrane potential by 20% in HepG2 cells when incubated at 20 μM for 1 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human hepatoma HepG2 cells
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Concentration:20 μM
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Incubation Time:6 h
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Result:Induced less pronounced activation of caspase-3, caspase-7, and caspase-9, as well as PARP-1 cleavage, compared to long-chain carboxychromanol metabolites.
Chemical Information
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CAS No. 1308347-24-1
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Masse moléculaire 418.65
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Formule C27H46O3
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SMILES
CC1=C2C(CC[C@](C)(O2)CCCC(C)CCCC(C)CCCC(C)CO)=CC(O)=C1
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
13′-Hydroxy-δ-tocopherol Related Classifications
HY-N17652 Related Classifications
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