2,3-Butanediol
Based on 1 Customer Validation
2,3-Butanediol is microbially derived compound that is a discriminating urinary biomarker of Fmo5-/- mice. 2,3-Butanediol prevents age-related increases in the plasma concentration of cholesterol. 2,3-Butanediol has potential applications in the manufacture of printing inks, perfumes, fumigants, moistening and softening agents, plasticizers, and as a carrier for pharmaceuticals.
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- Pureté: 99.96%
- CAS No.: 513-85-9
- Formule: C4H10O2
- Masse moléculaire:90.12
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Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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2,3-Butanediol contains two stereo centers, resulting in three stereo isomers including (2R,3R)-, meso- and (2S,3S)-forms[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Short- (4-week) and long-term (14-week) treatment of wild-type mice with a 2,3-Butanediol isomer mix decrease plasma cholesterol and epididymal fat deposition but have no effect on plasma concentrations of glucose or insulin, or on body weight. In the case of long-term treatment, the effects are maintained after withdrawal of 2,3-Butanediol. Short-, but not long-term treatment, also decreases plasma concentrations of triglycerides and non-esterified fatty acids[2].
The isomers of 2,3-Butanediol are discriminating urinary biomarkers of Fmo5-/- mice. Antibiotic treatment of Fmo5-/- mice increased plasma cholesterol concentrations and substantially reduced urinary excretion of 2,3-Butanediol, showing that gut bacteria contribute to the lower plasma cholesterol of Fmo5−/− mice, and that 2,3-Butanediol is microbially derived[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wild-type mice (aged 13 weeks)[2]
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Dosage:60 mg/kg/d, 250 mg/kg/d or 600 mg/kg/d (4:1:1 ratio of meso-2,3-Butanediol : 2R,3R-Butanediol : 2S,3S-Butanediol)
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Administration:Orally in drinking water; for 4 weeks
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Result:At a dose of 250 mg/kg/d, plasma concentrations of both total cholesterol and HDL cholesterol were significantly lower than those of mice that were untreated for 4 weeks.
At doses of 60 or 600 mg/kg/d did not prevent age-related increases in plasma concentrations of either total or HDL cholesterol.
Chemical Information
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CAS No. 513-85-9
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Appearance Liquid (Density: 1.002 g/cm3)
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Masse moléculaire 90.12
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Formule C4H10O2
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Color Colorless to off-white
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SMILES
CC(O)C(O)C
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvant et solubilité
H2O : 100 mg/mL (1109.63 mM; Need ultrasonic)
DMSO : 100 mg/mL (1109.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (27.74 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (27.74 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 140 mg/mL (1553.48 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (274 KB)
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SDS (255 KB)
- English - EN (255 KB)
- Français - FR (255 KB)
- Deutsch - DE (255 KB)
- Norwegian - NO (255 KB)
- Español - ES (255 KB)
- Swedish - SV (255 KB)
- Italian - IT (255 KB)
- Korean - KR (255 KB)
- Portuguese - PT (255 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Zhang L, et al. Mechanism of 2,3-butanediol stereoisomers formation in a newly isolated Serratia sp. T241. Sci Rep. 2016 Jan 12;6:19257. [Content Brief]
[2]. Veeravalli S, et al. Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5-/- mice, decreases plasma cholesterol and epididymal fat deposition. Front Physiol. 2022 Aug 8;13:859681. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 11.0963 mL | 55.4816 mL | 110.9632 mL | 277.4079 mL |
| 5 mM | 2.2193 mL | 11.0963 mL | 22.1926 mL | 55.4816 mL | |
| 10 mM | 1.1096 mL | 5.5482 mL | 11.0963 mL | 27.7408 mL | |
| 15 mM | 0.7398 mL | 3.6988 mL | 7.3975 mL | 18.4939 mL | |
| 20 mM | 0.5548 mL | 2.7741 mL | 5.5482 mL | 13.8704 mL | |
| 25 mM | 0.4439 mL | 2.2193 mL | 4.4385 mL | 11.0963 mL | |
| 30 mM | 0.3699 mL | 1.8494 mL | 3.6988 mL | 9.2469 mL | |
| 40 mM | 0.2774 mL | 1.3870 mL | 2.7741 mL | 6.9352 mL | |
| 50 mM | 0.2219 mL | 1.1096 mL | 2.2193 mL | 5.5482 mL | |
| 60 mM | 0.1849 mL | 0.9247 mL | 1.8494 mL | 4.6235 mL | |
| 80 mM | 0.1387 mL | 0.6935 mL | 1.3870 mL | 3.4676 mL | |
| 100 mM | 0.1110 mL | 0.5548 mL | 1.1096 mL | 2.7741 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
2,3-Butanediol Related Classifications
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