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Cat. No.: HY-137418

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2-MeS-ATP

(Synonyms: 2-Methylthio-ATP)

2-MeS-ATP (2-Methylthio-ATP) is an analog of adenosine nucleotides and acts as a P2Y purinergic receptor agonist specific for adenosine nucleotide activation. 2-MeS-ATP is also able to inhibit the release of toxic mediators from macrophages stimulated by endotoxin (LPS). 2-MeS-ATP can be used in the study of endotoxin shock and inflammatory diseases.

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CAS No.: 43170-89-4
Formule: C₁₁H₁₈N₅O₁₃P₃S
Masse moléculaire:553.27

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

2-MeS-ATP Chemical Structure

CAS No.: 43170-89-4

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform P2Y Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	1 nM Compound: 2	Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells	[PMID: 15317453]
Oocyte	EC₅₀	1500 nM Compound: 2-MeSATP	Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes	[PMID: 12213051]
Oocyte	EC₅₀	7400 nM Compound: 2-MeSATP	Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 30 uM, expressed in Xenopus oocytes Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 30 uM, expressed in Xenopus oocytes	[PMID: 12213051]

Chemical Information

CAS No. 43170-89-4
Masse moléculaire 553.27
Formule C₁₁H₁₈N₅O₁₃P₃S
SMILES

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(SC)N=C3N)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
Synonyms

2-Methylthio-ATP
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Proctor R A, et al. Protection of mice from endotoxic death by 2-methylthio-ATP[J]. Proceedings of the National Academy of Sciences, 1994, 91(13): 6017-6020. [Content Brief]

Calculators

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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2-MeS-ATP

Voir tous les produits spécifiques à Isoform P2Y Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

2-MeS-ATP Related Classifications

HY-137418 Related Classifications