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Cat. No.: HY-W092067

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6-Hydroxyisatin

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6-Hydroxyisatin is an atrial natriuretic peptide receptor (ANP receptor) inhibitor. 6-Hydroxyisatin exhibits inhibitory activity against ANP-stimulated particulate guanylyl cyclase activity in rat brain cell membranes.

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Pureté: 95.86%
CAS No.: 116569-08-5
Formule: C₈H₅NO₃
Masse moléculaire:163.13

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

6-Hydroxyisatin Chemical Structure

CAS No.: 116569-08-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

In Vitro

6-Hydroxyisatin (50 μM) inhibits ANP-stimulated particulate guanylyl cyclase activity in rat brain membranes by 54.4%^[2].
6-Hydroxyisatin (50 μM) inhibits ANP-stimulated particulate guanylyl cyclase activity in rat heart membranes by 16.7%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 116569-08-5
Appearance Solid
Masse moléculaire 163.13
Formule C₈H₅NO₃
Color Orange to red
SMILES

O=C1NC2=C(C=CC(O)=C2)C1=O
Structure Classification
- Others
Initial Source
- Microorganisms
Micromonospora carbonacea
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
SDS (394 KB)
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- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Khaled A. Shaaban, et al. Structure elucidation and synthesis of
hydroxylated isatins from Streptomycetes. Z. Naturforsch. 2016; 71(12)b: 1191-1198

[2]. Medvedev AE, et al. Efficacy of isatin analogues as antagonists of rat brain and heart atrial natriuretic peptide receptors coupled to particulate guanylyl cyclase. Biochem Pharmacol. 1999;57(8):913-915. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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6-Hydroxyisatin

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6-Hydroxyisatin

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6-Hydroxyisatin Related Classifications

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