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Cat. No.: HY-118668

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ABD-350

ABD-350 is an antiresorptive agent that inhibits osteoclast activity without affecting osteoblast activity and preventing ovariectomy-induced bone loss. ABD-350 inhibits NF-κB ligand-induced inhibitor of NF-κB phosphorylation, leading to osteoclast apoptosis, but has no inhibitory effect on osteoblast function, effectively preventing bone loss in ovariectomized mice, and does not inhibit parathyroid hormone-induced bone formation.

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CAS No.: 1117772-52-7
Formule: C₁₉H₂₂F₂O₂
Masse moléculaire:320.37

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

ABD-350 Chemical Structure

CAS No.: 1117772-52-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform NF-κB :

Cellular Effect

Cell Line	Type	Value	Description	References
J774	IC₅₀	8 μM Compound: 3u	Cytotoxicity against mouse J774 cells expressing RANKL signaling by Alamar blue assay Cytotoxicity against mouse J774 cells expressing RANKL signaling by Alamar blue assay	[PMID: 20692834]
Osteoblast	IC₅₀	>100 μM Compound: 3u	Cytotoxicity against mouse osteoblast cells by alamar blue assay Cytotoxicity against mouse osteoblast cells by alamar blue assay	[PMID: 20692834]
Osteoclast	IC₅₀	1.3 μM Compound: 3u	Cytotoxicity against mouse osteoclast cells expressing RANKL signaling by Alamar blue assay Cytotoxicity against mouse osteoclast cells expressing RANKL signaling by Alamar blue assay	[PMID: 20692834]

Chemical Information

CAS No. 1117772-52-7
Masse moléculaire 320.37
Formule C₁₉H₂₂F₂O₂
SMILES

OC(CCCCCO)C1=CC=C(C(C)=C1)C2=CC=C(C=C2F)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Identification of novel biphenyl carboxylic acid derivatives as novel antiresorptive agents that do not impair parathyroid hormone-induced bone formation [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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