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Cat. No.: HY-W728130

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Abemaciclib-d₅

(Synonyms: LY2835219-d₅)

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Based on 1 Customer Validation

Abemaciclib-d5 (LY2835219-d5) is a deuterium labeled Abemaciclib (HY-16297A).

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CAS No.: 1809251-51-1
Formule: C₂₇H₂₇D₅F₂N₈
Masse moléculaire:511.62

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Abemaciclib-d₅ Chemical Structure

CAS No.: 1809251-51-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Application
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Abemaciclib-d5 (LY2835219-d5) is a deuterium labeled Abemaciclib (HY-16297A)^[1]^[2]^[3].

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 1809251-51-1
Unlabeled Cas 1231929-97-7
Masse moléculaire 511.62
Formule C₂₇H₂₇D₅F₂N₈
SMILES

CC(N1C(C)C)=NC(C1=CC(C2=C(C=NC(NC3=CC=C(CN4CCN(C([2H])(C([2H])([2H])[2H])[2H])CC4)C=N3)=N2)F)=C5)=C5F
Synonyms

LY2835219-d₅
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ku BM, et al. The CDK4/6 inhibitor LY2835219 has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma. Oncotarget. 2016 Mar 22;7(12):14803-13. [Content Brief]

[2]. Yadav V, et al. The CDK4/6 inhibitor LY2835219 overcomes vemurafenib resistance resulting from MAPK reactivation and cyclin D1 upregulation. Mol Cancer Ther. 2014 Oct;13(10):2253-63. [Content Brief]

[3]. Gelbert LM, et al. Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine. Invest New Drugs. 2014 Oct;32(5):825-37. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Pureté et documentation
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Abemaciclib-d5

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Abemaciclib-d5 Related Classifications

HY-W728130 Related Classifications

Abemaciclib-d₅

Abemaciclib-d₅ Related Classifications