AC-386
AC-386 is a highly potent c-Met inhibitor with IC50 value of 7.42 nM. AC-386 has antiproliferative activities against certain cancer cell lines. AC-386 can be used for researching anti-cancer resistance.
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- CAS No.: 1902910-89-7
- Formule: C35H34FN5O6
- Masse moléculaire:639.67
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.12 μM
Compound: AC-386
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Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
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[PMID: 32738414] |
| HCT-116 | IC50 |
0.37 μM
Compound: AC-386
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
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[PMID: 32738414] |
| MCF7 | IC50 |
0.63 μM
Compound: AC-386
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
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[PMID: 32738414] |
AC-386 (0-20 μM; 72 hours) exhibits antiproliferative activities against HCT-116, MCF-7 and A549[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116, MCF-7 and A549[1]
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Concentration:0-20 μM
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Incubation Time:72 hours
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Result:Exhibited antiproliferative activities against HCT-116, MCF-7 and A549 with IC50s of 0.37 ± 0.02 μM, 0.63 ± 0.05 μM, 1.12 ± 0.10 μM in HCT-116, MCF-7 and A549, respectively.
Chemical Information
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CAS No. 1902910-89-7
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Masse moléculaire 639.67
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Formule C35H34FN5O6
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SMILES
O=C(C1=NN(C2=CC=CC=C2)C=C(C)C1=O)NC3=CC=C(OC4=CC=NC5=CC(OCCCN6CCOCC6)=C(OC)C=C45)C(F)=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AC-386 Related Classifications
HY-143463 Related Classifications
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