AGI-12026
AGI-12026 is brain-penetrant dual inhibitor of mutant IDH1 and 2. AGI-12026 shows partial inhibition of the IDH1-R132H homodimer as allosteric modulators. AGI-12026 has the potential for research of glioma.
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- CAS No.: 1446501-77-4
- Formule: C18H15F6N7
- Masse moléculaire:443.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
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| Sf9 | IC50 |
0.019 μM
Compound: AGI-12026
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Inhibition of full-length C-terminal His6 tagged IDH2 R140Q mutant (1 to 452 residues) (unknown origin) homodimer expressed in Sf9 cells assessed as reduction in NADPH consumption using alpha-ketoglutarate as substrate preincubated for 16 hrs followed by
Inhibition of full-length C-terminal His6 tagged IDH2 R140Q mutant (1 to 452 residues) (unknown origin) homodimer expressed in Sf9 cells assessed as reduction in NADPH consumption using alpha-ketoglutarate as substrate preincubated for 16 hrs followed by
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[PMID: 32071674] |
Chemical Information
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CAS No. 1446501-77-4
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Masse moléculaire 443.35
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Formule C18H15F6N7
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SMILES
FC(F)(F)C1=CC=CC(C2=NC(NC(C)C)=NC(NC3=CC(C(F)(F)F)=NC=C3)=N2)=N1
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Synonyms
AGI-026
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AGI-12026 Related Classifications
HY-121736 Related Classifications
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