AKI-001
AKI-001 is an prototype pentacyclic inhibitor of aurora kinase with cellular potency of IC50 of less than 100 nM. AKI-001 shows low nanomolar potency against Aurora A and Aurora B enzymes.
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- CAS No.: 925218-37-7
- Formule: C21H24N4O
- Masse moléculaire:348.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.07 μM
Compound: 32, AKI-001
|
Antiproliferative activity against human HCT116 cells
Antiproliferative activity against human HCT116 cells
|
[PMID: 18630890] |
| HT-29 | IC50 |
0.07 μM
Compound: 32, AKI-001
|
Antiproliferative activity against human HT29 cells
Antiproliferative activity against human HT29 cells
|
[PMID: 18630890] |
| MCF7 | IC50 |
0.1 μM
Compound: 32, AKI-001
|
Antiproliferative activity against human MCF7 cells
Antiproliferative activity against human MCF7 cells
|
[PMID: 18630890] |
| MOLT-4 | IC50 |
0.11 μM
Compound: 32, AKI-001
|
Cell cycle arrested in human MOLT4 cells assessed as accumulation at G2/M phase after 24 hrs
Cell cycle arrested in human MOLT4 cells assessed as accumulation at G2/M phase after 24 hrs
|
[PMID: 18630890] |
Chemical Information
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CAS No. 925218-37-7
-
Masse moléculaire 348.44
-
Formule C21H24N4O
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SMILES
O=C1C(C)(C)C2=CC3=C(C=C2N1CC)C(CCCC4=C(C)NN=C45)=C5N3
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Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)