AL-611
Based on 1 Customer Validation
AL-611 is an HCV NS5B polymerase inhibitor (EC50 = 5 nM).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.93%
- CAS No.: 2481279-61-0
- Formule: C25H33F2N6O8P
- Masse moléculaire:614.54
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
>100 μM
Compound: 40
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Cytotoxicity against human A549 cells incubated for 8 days by cellTiter-Glo assay
Cytotoxicity against human A549 cells incubated for 8 days by cellTiter-Glo assay
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[PMID: 32816483] |
| HeLa | CC50 |
>100 μM
Compound: 40
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Cytotoxicity against human HeLa cells incubated for 8 days by cellTiter-Glo assay
Cytotoxicity against human HeLa cells incubated for 8 days by cellTiter-Glo assay
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[PMID: 32816483] |
| HepG2 | CC50 |
>100 μM
Compound: 40
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Cytotoxicity against human HepG2 cells incubated for 8 days by cellTiter-Glo assay
Cytotoxicity against human HepG2 cells incubated for 8 days by cellTiter-Glo assay
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[PMID: 32816483] |
| Huh-7 | CC50 |
>100 μM
Compound: 40
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Cytotoxicity against human HuH7 cells incubated for 8 days by cellTiter-Glo assay
Cytotoxicity against human HuH7 cells incubated for 8 days by cellTiter-Glo assay
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[PMID: 32816483] |
| Huh-7 | CC50 |
>100 μM
Compound: 40
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Cytotoxicity against human HuH7 cells infected with HCV con1 subgenomic replicon assessed as reduction in cell viability measured after 3 days by CellTiter-blue cell viability assay
Cytotoxicity against human HuH7 cells infected with HCV con1 subgenomic replicon assessed as reduction in cell viability measured after 3 days by CellTiter-blue cell viability assay
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[PMID: 32816483] |
| MT4 | CC50 |
92 μM
Compound: 40
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Cytotoxicity against human MT4 cells incubated for 8 days by cellTiter-Glo assay
Cytotoxicity against human MT4 cells incubated for 8 days by cellTiter-Glo assay
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[PMID: 32816483] |
| U-937 | CC50 |
10 μM
Compound: 40
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Cytotoxicity against human U937 cells incubated for 8 days by cellTiter-Glo assay
Cytotoxicity against human U937 cells incubated for 8 days by cellTiter-Glo assay
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[PMID: 32816483] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2481279-61-0
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Appearance Solid
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Masse moléculaire 614.54
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Formule C25H33F2N6O8P
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Color White to off-white
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SMILES
C[C@@]1([C@](O[C@@](F)([C@H]1O)CO[P@](OC2=CC=CC=C2)(N[C@@H](C)C(OC(C)C)=O)=O)([H])N3C4=NC(N)=NC(OCC)=C4N=C3)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 125 mg/mL (203.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6272 mL | 8.1362 mL | 16.2723 mL | 40.6808 mL |
| 5 mM | 0.3254 mL | 1.6272 mL | 3.2545 mL | 8.1362 mL | |
| 10 mM | 0.1627 mL | 0.8136 mL | 1.6272 mL | 4.0681 mL | |
| 15 mM | 0.1085 mL | 0.5424 mL | 1.0848 mL | 2.7121 mL | |
| 20 mM | 0.0814 mL | 0.4068 mL | 0.8136 mL | 2.0340 mL | |
| 25 mM | 0.0651 mL | 0.3254 mL | 0.6509 mL | 1.6272 mL | |
| 30 mM | 0.0542 mL | 0.2712 mL | 0.5424 mL | 1.3560 mL | |
| 40 mM | 0.0407 mL | 0.2034 mL | 0.4068 mL | 1.0170 mL | |
| 50 mM | 0.0325 mL | 0.1627 mL | 0.3254 mL | 0.8136 mL | |
| 60 mM | 0.0271 mL | 0.1356 mL | 0.2712 mL | 0.6780 mL | |
| 80 mM | 0.0203 mL | 0.1017 mL | 0.2034 mL | 0.5085 mL | |
| 100 mM | 0.0163 mL | 0.0814 mL | 0.1627 mL | 0.4068 mL |
AL-611 Related Classifications
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