AM1172
AM1172 is metabolically stable anandamide uptake inhibitor. AM1172 inhibits [3H] anandamide transport in rat cortical neurons and human CCF-STTG1 astrocytoma cells with IC50 values of 2.1 μM and 2.5 μM, respectively. AM1172 can significantly inhibit AEA hydrolysis and concurrently decrease AEA uptake. AM1172 can be used for the study of endocannabinoid system regulation.
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- CAS No.: 251908-92-6
- Formule: C27H39NO2
- Masse moléculaire:409.60
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Stockage:
Solution, -20°C, 2 years
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
AM1172 inhibits [3H] anandamide transport in rat cortical neurons and human CCF-STTG1 astrocytoma cells with IC50 values of 2.1 μM and 2.5 μM, respectively[1].
AM1172 (10-30 μM, 5 min) significantly reduces [14C]AEA hydrolysis in RBL-2H3 cells and concurrently decreases [14C]AEA uptake[2].
AM1172 shows moderate affinities for G protein-coupled CB1(IC50 = 271 nM) and CB2 receptors (IC50 = 189 nM)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 251908-92-6
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Appearance Liquid
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Masse moléculaire 409.60
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Formule C27H39NO2
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Color Colorless to light yellow
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SMILES
O=C(NCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)C1=CC=C(O)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Solution, -20°C, 2 years
Pureté et documentation
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Fiche technique (262 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Fegley D, et al. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8756-61. [Content Brief]
[2]. Kaczocha M, et al. Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase. J Biol Chem. 2006 Apr 7;281(14):9066-75. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AM1172 Related Classifications
HY-103338 Related Classifications
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