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Cat. No.: HY-187615

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AM4299 A

AM4299 A is a thiol protease inhibitor with IC₅₀ values of 73, 390 and 88 nM against Cathepsin B, Cathepsin L and Papain, respectively. AM4299 A shows low toxicity and favorable biosafety in mice. AM4299 A can be used in studies related to osteoporosis and parasitic diseases.

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CAS No.: 160825-48-9
Formule: C₁₅H₂₆N₂O₆
Masse moléculaire:330.38

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AM4299 A Chemical Structure

CAS No.: 160825-48-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

Cathepsin C

73 nM (IC₅₀)

cathepsin L

390 nM (IC₅₀)

papain

88 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Cathepsin :

In Vitro

Lysosomal Metabolism

AM4299 A specifically inhibits purified bovine spleen cathepsin B (IC₅₀ = 7.3 × 10^-8 M), human kidney cathepsin L (IC₅₀ = 3.9 × 10^-7 M), and Carica papaya papain (IC₅₀ = 8.8 × 10^-8 M), with no activity against bovine pancreas trypsin or α-chymotrypsin at concentrations up to 8.0 × 10^-5 M^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AM4299 A (intravenous injection; 200 mg/kg) causes no mortality and exhibits low acute toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 160825-48-9
Masse moléculaire 330.38
Formule C₁₅H₂₆N₂O₆
SMILES

C(N[C@H](C(NCCCCCO)=O)CC(C)C)(=O)C1C(C(O)=O)O1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Morishita A, et al. AM4299 A and B, novel thiol protease inhibitors[J]. The Journal of Antibiotics, 1994, 47(9): 1065-1068.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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