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Cat. No.: HY-106720

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Amosulalol

(Synonyms: YM 09538)

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Amosulalol (YM 09538) is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR).

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Pureté: 98.69%
CAS No.: 85320-68-9
Formule: C₁₈H₂₄N₂O₅S
Masse moléculaire:380.46

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Amosulalol Chemical Structure

CAS No.: 85320-68-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
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Classifications
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Activité biologique

Description

IC₅₀ & Target^[1]

α1-adrenergic receptor

Beta-1 adrenergic receptor

Voir tous les produits spécifiques à Isoform Adrenergic Receptor :

In Vivo

Amosulalol (3-30 mg/kg; p.o.; single dose) reduces acute systolic blood pressure in hypertensive rats^[1].
Amosulalol (50 mg/kg; p.o.; twice daily for 12 weeks) produces an intolerant antihypertensive effect and also reduces central rate and increases PRA in hypertensive rat models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 85320-68-9
Appearance Solid
Masse moléculaire 380.46
Formule C₁₈H₂₄N₂O₅S
Color White to off-white
SMILES

NS(=O)(C1=CC(C(O)CNCCOC2=C(C=CC=C2)OC)=CC=C1C)=O
Synonyms

YM 09538
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Honda K, et al. Autonomic and antihypertensive activity of oral amosulalol (YM-09538), a combined alpha- and beta-adrenoceptor blocking agent in conscious rats. Jpn J Pharmacol. 1985 May;38(1):31-41. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références

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Amosulalol

Voir tous les produits spécifiques à Isoform Adrenergic Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Amosulalol Related Classifications

HY-106720 Related Classifications