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Cat. No.: HY-158005

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Anticancer agent 195

Anticancer agent 195 (Compound 10) is an inhibitor for ELF3-MED23 PPI with K_i of 0.68 μM. Anticancer agent 195 induces apoptosis and exhibits antitumor activity.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₄H₂₈O₆
Masse moléculaire:412.48

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Anticancer agent 195 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Anticancer agent 195 (Compound 10) is an inhibitor for ELF3-MED23 PPI with K_i of 0.68 μM. Anticancer agent 195 induces apoptosis and exhibits antitumor activity^[1].

IC₅₀ & Target

>K_i: 0.68 μM (ELF3-MED23 PPI)

In Vitro

Anticancer agent 195 (10 μM) blocks the ELF3-MED23 interaction, inhibits activity of HER2 promoter and followed phosphorylation of AKT and MAPK^[1].
Anticancer agent 195 (10 μM) reveals an anti-proliferative and apoptotic-inducing efficacy in cells NCI-N87, exhibits potency against trastuzumab resistance^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

NCI-N87, NCI-N87 TR
Concentration:

0-10 μM
Incubation Time:

16 h
Result:

Reduced levels of HER2, phosphorylated AKT and p-MAPK.
Increased cleaved PARP and c-caspase 3.

Apoptosis Analysis^[1]

Cell Line:

NCI-N87, NCI-N87 TR
Concentration:

0-15 μM
Incubation Time:

24 h
Result:

Induced apoptosis in a dose-dependent manner.

In Vivo

Anticancer agent 195 (4 mg/kg, i.v. for 25 days) inhibited tumor growth in NCI-N87 xenograft athymic nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NCI-N87 xenograft athymic nude mice^[1]
Dosage:

4 mg/kg
Administration:

i.v., every three days for 25 days
Result:

Inhibited tumor growth.

Chemical Information

Masse moléculaire 412.48
Formule C₂₄H₂₈O₆
SMILES

COC1=CC(C(/C=C/C2=CC=C(C(OC/C=C(C)\C)=C2)OC)=O)=CC(OC)=C1OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hwang SY, et al., Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as Novel Inhibitor for ELF3-MED23 Interaction, Cold Spring Harbor Laboratory, 2024

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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