Anticancer agent 230
Based on 1 Customer Validation
Anticancer agent 230 (example 65) is a caseinolytic protease P (ClpP) activator with anticancer activity. Anticancer agent 230 is able to induce the degradation of mitochondrial proteins in SUM159 and MDA-MB-231 triple-negative breast cancer cells in a time-dependent manner.
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- Pureté: 99.97%
- CAS No.: 2485052-87-5
- Formule: C22H19ClN4O
- Masse moléculaire:390.87
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Anti-Breast Cancer Compound Library
HY-L074
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
3 nM
Compound: 9; TR-107
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst stain-based assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst stain-based assay
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[PMID: 37974956] |
| SUM-159-PT | IC50 |
12 nM
Compound: 9; TR-107
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Antiproliferative activity against human SUM159 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst stain-based assay
Antiproliferative activity against human SUM159 cells assessed as inhibition of cell growth incubated for 72 hrs by Hoechst stain-based assay
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[PMID: 37974956] |
Chemical Information
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CAS No. 2485052-87-5
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Appearance Solid
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Masse moléculaire 390.87
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Formule C22H19ClN4O
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Color White to off-white
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SMILES
N#CC1=CC=CC(CN(C2)CCC(N=CN3CC4=CC=C(Cl)C=C4)=C2C3=O)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 50 mg/mL (127.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5584 mL | 12.7920 mL | 25.5840 mL | 63.9599 mL |
| 5 mM | 0.5117 mL | 2.5584 mL | 5.1168 mL | 12.7920 mL | |
| 10 mM | 0.2558 mL | 1.2792 mL | 2.5584 mL | 6.3960 mL | |
| 15 mM | 0.1706 mL | 0.8528 mL | 1.7056 mL | 4.2640 mL | |
| 20 mM | 0.1279 mL | 0.6396 mL | 1.2792 mL | 3.1980 mL | |
| 25 mM | 0.1023 mL | 0.5117 mL | 1.0234 mL | 2.5584 mL | |
| 30 mM | 0.0853 mL | 0.4264 mL | 0.8528 mL | 2.1320 mL | |
| 40 mM | 0.0640 mL | 0.3198 mL | 0.6396 mL | 1.5990 mL | |
| 50 mM | 0.0512 mL | 0.2558 mL | 0.5117 mL | 1.2792 mL | |
| 60 mM | 0.0426 mL | 0.2132 mL | 0.4264 mL | 1.0660 mL | |
| 80 mM | 0.0320 mL | 0.1599 mL | 0.3198 mL | 0.7995 mL | |
| 100 mM | 0.0256 mL | 0.1279 mL | 0.2558 mL | 0.6396 mL |
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