Anticancer agent 99
Anticancer agent 99 (compound 2p) has good anticancer activity against HepG2 cells, with an IC50 value of 35.9 μM. Anticancer agent 99 can induce apoptosis and has anti-proliferation effect.
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- CAS No.: 2914922-83-9
- Formule: C19H20F3N3O2
- Masse moléculaire:379.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Anticancer agent 99 (0-50 μM, 24 h) directly upregulates Bax expression and induces caspase-3-dependent apoptosis in HepG2 cell line, with antiproliferative effects[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cell
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Concentration:25, 50 μM
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Incubation Time:24 h
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Result:Increased mRNA transcript levels of pro-apoptotic Bax and Caspase-3 genes.
Reduced Akt protein levels in HepG2 cells.
Increased FoXO1, TXNIP and p27 protein levels in HepG2 cells.
Chemical Information
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CAS No. 2914922-83-9
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Masse moléculaire 379.38
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Formule C19H20F3N3O2
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SMILES
O=C(C1=CC=C(NCCCC)C=C1)N/N=C/C2=C(OC(F)(F)F)C=CC=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 99 Related Classifications
HY-149061 Related Classifications
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