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Cat. No.: HY-169194

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Antimalarial agent 44

Antimalarial agent 44 (Compound 3) is an antimalarial agent against parasite. Antimalarial agent 44 has a good permeability across MDCK-MDR1 cell monolayers and a high clearance by mouse liver microsomes.

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Formule: C₃₇H₃₇N₅O₇
Masse moléculaire:663.72

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Antimalarial agent 44 Chemical Structure

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Parasite :

Cellular Effect

Cell Line	Type	Value	Description	References
MRC5	CC₅₀	>64 μM Compound: 3	Cytotoxicity against human MRC5 cells Cytotoxicity against human MRC5 cells	[PMID: 39378318]
Peritoneal macrophage	CC₅₀	>64 μM Compound: 3	Cytotoxicity against mouse Peritoneal macrophage Cytotoxicity against mouse Peritoneal macrophage	[PMID: 39378318]

In Vitro

Antimalarial agent 44 inhibits Leishmania infantum, Plasmodium falciparum, Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense and Trypanosoma cruzi (EC₅₀: 1.8, 3, 15, 9.1, 20 μM, respectively) ^[1].
Antimalarial agent 44 (pH 7.4) has a good cell permeability across MDCK-MDR1 cell monolayers, with P_app AB of 3.5 μcm/s^[1].
Antimalarial agent 44 (pH 7.4) was efficiently cleared in mouse liver microsomes, with CL_int of >580 μL/min/mg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Masse moléculaire 663.72
Formule C₃₇H₃₇N₅O₇
SMILES

O=C(C1=CC(NC(C2=NC=CC=C2)=O)=C(C=C1)OC3=CC=C(C[C@@H]4NC(OC(C)(C)C)=O)C=C3)CNC([C@H](CC5=CC=CC=C5)NC4=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Riu, et al. Discovery of a Series of Macrocycles as Potent Inhibitors of Leishmania Infantum. Journal of medicinal chemistry, 2024, 67(20):18170-18193. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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