As-358
As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC50s of 47.5 μM and 3.7 μM.
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- CAS No.: 2222042-47-7
- Formule: C18H31NO2
- Masse moléculaire:293.44
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Stockage:
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
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EBOV |
MARV |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
302 μM
Compound: 4
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Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 30108738] |
| HEK-293T | CC50 |
289.7 μM
Compound: 3b; As-358
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Cytotoxicity against human HEK293T cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HEK293T cells incubated for 48 hrs by MTT assay
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[PMID: 32905862] |
| MDCK | CC50 |
69.6 μM
Compound: 14
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Cytotoxicity against MDCK cells after 48 hrs by MTT assay
Cytotoxicity against MDCK cells after 48 hrs by MTT assay
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[PMID: 30108810] |
| Vero | CC50 |
442.9 μM
Compound: 3b; As-358
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis
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[PMID: 32905862] |
In Vitro
As-358 (compound 3b) (0-500 μM; 10 days) exhibits inhibitory activities against EBOV and MARV[1].
As-358 (0-100 μM; 48 hours) can inhibit WT-EboV-GP and mutant D522A-EboV-GP, with IC50s of 1.7 and 2.2 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:Vero (infected with EBOV and MARV)[1]
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Concentration:0-500 μM
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Incubation Time:10 days
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Result:Exhibited inhibitory activities against EBOV and MARV, with IC50s of 47.5 ± 8.2 μM and 3.7 ± 1.7 μM, SI values of 9 and 118, respectively.
Chemical Information
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CAS No. 2222042-47-7
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Masse moléculaire 293.44
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Formule C18H31NO2
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SMILES
O=C(O[C@@H]1C[C@@H]2CC[C@]1(C2(C)C)C)CCN3CCCCC3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
As-358 Related Classifications
HY-146883 Related Classifications
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