AT-076
AT-076 is an opioid pan antagonist at nociception, kappa, mu, and delta opioid receptors, with Ki values of 1.75 nM (NOP), 1.67 nM (MOP), 1.14 nM (KOP) and 19.6 nM (DOP), respectively.
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- CAS No.: 1657028-64-2
- Formule: C26H35N3O3
- Masse moléculaire:437.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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NOP Receptor/ORL1 1.75 nM (IC50) |
μ Opioid Receptor/MOR 1.67 nM (IC50) |
κ Opioid Receptor/KOR 1.14 nM (IC50) |
δ Opioid Receptor/DOR 19.6 nM (IC50) |
Chemical Information
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CAS No. 1657028-64-2
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Masse moléculaire 437.57
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Formule C26H35N3O3
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SMILES
OC1=CC=CC(C(CC2)CCN2C[C@H](C(C)C)NC([C@H]3CC4=CC=C(O)C=C4CN3)=O)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Nurulain T Zaveri, et al. Discovery of the first small-molecule opioid pan antagonist with nanomolar affinity at mu, delta, kappa, and nociceptin opioid receptors. ACS Chem Neurosci. 2015 Apr 15;6(4):646-57. [Content Brief]
[2]. V Blair Journigan, et al. Probing ligand recognition of the opioid pan antagonist AT-076 at nociceptin, kappa, mu, and delta opioid receptors through structure-activity relationships. Sci Rep. 2017 Oct 16;7(1):13255. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AT-076 Related Classifications
HY-106732 Related Classifications
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