BAY-277
BAY-277, a chemical probe, is a METAP2 degrader, with IC50 values of 5.8 nM and 5.9 nM for hMETAP2 and mMETAP2, respectively.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C44H52N8O5
- Masse moléculaire:772.93
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-1080 | DC50 |
8.93 nM
Compound: EUB0003014
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Degradation in HT1080 cells (CE) (Capillary electrophoresis (CE))
Degradation in HT1080 cells (CE) (Capillary electrophoresis (CE))
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10.6019/CHEMBL5463725 |
| HUVEC | DC50 |
0.2 nM
Compound: EUB0003014
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Degradation in HUVEC cells (WB) (Western Blot (WB))
Degradation in HUVEC cells (WB) (Western Blot (WB))
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10.6019/CHEMBL5463725 |
| HUVEC | IC50 |
12 nM
Compound: EUB0003014
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2D HUVEC cells proliferation assay
2D HUVEC cells proliferation assay
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10.6019/CHEMBL5463725 |
BAY-277 exhibits DC50 of 8.93 nM for the degradation in HT1080 cells (CE), DC50 of 0.2 nM for the degradation in HUVEC cells (WB) and IC50 of 12 nM in the 2D HUVEC cells proliferation assay.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 772.93
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Formule C44H52N8O5
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SMILES
O=C(N1CCC(C2=CC=C3C(CN(C4C(NC(CC4)=O)=O)C3=O)=C2)CC1)CCCCCN(CC5)CCC5C6=CC=C(C=C6)OC7=NN8C(C9=C7CCCC9)=NN=C8
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BAY-277 Related Classifications
HY-168967 Related Classifications
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