Bim-IN-1
Based on 1 Customer Validation
Bim-IN-1 is a potent Bim expression inhibitor. Bim-IN-1 reduces Bim expression levels and has little inhibitory effect upon protein kinase A activity and minimal toxicity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.12%
- CAS No.: 2909483-36-7
- Formule: C19H20Cl2FNO2S
- Masse moléculaire:416.34
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
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Bim |
In Vitro
Bim-IN-1 (compound 63, mouse embryonic fibroblasts; 0, 25, 50 μM; 72 hours) demonstrates strong reduction of Bim expression levels at a low micromolar level with low toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2909483-36-7
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Appearance Solid
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Masse moléculaire 416.34
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Formule C19H20Cl2FNO2S
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Color White to light yellow
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SMILES
FC1=CC(C2N(S(=O)(CC3=CC=C(Cl)C=C3Cl)=O)CCCCC2)=CC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 200 mg/mL (480.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
Pureté et documentation
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Fiche technique (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.4019 mL | 12.0094 mL | 24.0188 mL | 60.0471 mL |
| 5 mM | 0.4804 mL | 2.4019 mL | 4.8038 mL | 12.0094 mL | |
| 10 mM | 0.2402 mL | 1.2009 mL | 2.4019 mL | 6.0047 mL | |
| 15 mM | 0.1601 mL | 0.8006 mL | 1.6013 mL | 4.0031 mL | |
| 20 mM | 0.1201 mL | 0.6005 mL | 1.2009 mL | 3.0024 mL | |
| 25 mM | 0.0961 mL | 0.4804 mL | 0.9608 mL | 2.4019 mL | |
| 30 mM | 0.0801 mL | 0.4003 mL | 0.8006 mL | 2.0016 mL | |
| 40 mM | 0.0600 mL | 0.3002 mL | 0.6005 mL | 1.5012 mL | |
| 50 mM | 0.0480 mL | 0.2402 mL | 0.4804 mL | 1.2009 mL | |
| 60 mM | 0.0400 mL | 0.2002 mL | 0.4003 mL | 1.0008 mL | |
| 80 mM | 0.0300 mL | 0.1501 mL | 0.3002 mL | 0.7506 mL | |
| 100 mM | 0.0240 mL | 0.1201 mL | 0.2402 mL | 0.6005 mL |
Bim-IN-1 Related Classifications
HY-115930 Related Classifications
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