BMV109
BMV109 is a quenched probe that becomes fluorescent when cleaved and covalently bound by active cathepsin proteases. BMV109 can be exploited for tumor imaging.
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- CAS No.: 1458731-58-2
- Formule: C107H108F4N10O23S5
- Masse moléculaire:2138.37
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
BMV109 (compound 8; 0.05 µM, 0.1 µM, 0.5 µM, 1 µM, 5 µM) labels all target cysteine cathepsins (B, S, L, X) with equal intensity in living RAW cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice bearing 4T1 cells[1]
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Dosage:20 nmol
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Administration:Tail vein
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Result:Robust tumor specific activation of fluorescence with high overall intensity could be observed.
Chemical Information
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CAS No. 1458731-58-2
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Masse moléculaire 2138.37
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Formule C107H108F4N10O23S5
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SMILES
O=S(C1=C(C=CC=C1)C(C2=CC=C(N3C4=CC=C(S(=O)([O-])=O)C=C4CC3)C=C2O5)=C(C=C/6)C5=CC6=[N+]7C8=CC=C(S(=O)(O)=O)C=C8CC/7)(N9CCC(CC9)C(NCCNC(C%10=C(C(F)=C(C(F)=C%10F)OCC([C@H](CCCCNC(CCCCCN%11C%12=CC=C(S(=O)(O)=O)C=C%12C(C)(/C%11=C/C=C/C=C/C%13=[N+](C%14=CC=C(S(=O)([O-])=O)C=C%14C%13(C)C)CC)C)=O)NC([C@@H](NC(OCC%15=CC=CC=C%15)=O)CC%16=CC=CC=C%16)=O)=O)F)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Martijn Verdoes, et al. Improved quenched fluorescent probe for imaging of cysteine cathepsin activity. J Am Chem Soc. 2013 Oct 2;135(39):14726-30. [Content Brief]
[2]. Steven Sensarn, et al. A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer. Mol Imaging Biol. 2016 Dec;18(6):820-829. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMV109 Related Classifications
HY-149931 Related Classifications
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