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Cat. No.: HY-119899

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BO-0742

BO-0742, a derivative of AHMA and N-mustard, is a potent anti-cancer agent. BO-0742 significantly suppresses the growth of xenografts of human breast and ovarian cancers in mice.

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CAS No.: 774234-08-1
Formule: C₂₆H₂₇Cl₂N₃O₂
Masse moléculaire:484.42

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BO-0742 Chemical Structure

CAS No.: 774234-08-1

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

BO-0742, a derivative of AHMA and N-mustard, is a potent anti-cancer agent. BO-0742 significantly suppresses the growth of xenografts of human breast and ovarian cancers in mice^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.0056 μM Compound: 8	Antiproliferative activity against human A549 cell line Antiproliferative activity against human A549 cell line	[PMID: 16759114]
A549	IC₅₀	0.0056 μM Compound: 9	Concentration required for growth inhibition of human lung carcinoma cell line (CCRF-CEM) was determined Concentration required for growth inhibition of human lung carcinoma cell line (CCRF-CEM) was determined	[PMID: 15324894]
CCRF-CEM	IC₅₀	0.007 μM Compound: 6, BO-0742	Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay	[PMID: 19124250]
CCRF-CEM	IC₅₀	0.007 μM Compound: 8	Antiproliferative activity against human CCRF-CEM cell line Antiproliferative activity against human CCRF-CEM cell line	[PMID: 16759114]
CCRF-CEM	IC₅₀	0.007 μM Compound: 9	Concentration required for growth inhibition of human lymphoblastic leukemic cell line (CCRF-CEM) was determined Concentration required for growth inhibition of human lymphoblastic leukemic cell line (CCRF-CEM) was determined	[PMID: 15324894]
CCRF-CEM	IC₅₀	0.0075 μM Compound: 6, BO-0742	Cytotoxicity against taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay Cytotoxicity against taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay	[PMID: 19124250]
CCRF-CEM	IC₅₀	0.0075 μM Compound: 8	Antiproliferative activity against human vinblastine resistant CCRF-CEM cell line Antiproliferative activity against human vinblastine resistant CCRF-CEM cell line	[PMID: 16759114]
CCRF-CEM	IC₅₀	0.0075 μM Compound: 9	Concentration required for growth inhibition of vinblastine resistant human lymphoblastic leukemic cell line (CCRF-CEM/VBL) was determined Concentration required for growth inhibition of vinblastine resistant human lymphoblastic leukemic cell line (CCRF-CEM/VBL) was determined	[PMID: 15324894]
CCRF-CEM	IC₅₀	0.03 μM Compound: 9	Concentration required for growth inhibition of taxol resistant human lymphoblastic leukemic cell line (CCRF-CEM/taxol) was determined Concentration required for growth inhibition of taxol resistant human lymphoblastic leukemic cell line (CCRF-CEM/taxol) was determined	[PMID: 15324894]
CCRF-CEM	IC₅₀	0.034 μM Compound: 6, BO-0742	Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay	[PMID: 19124250]
CCRF-CEM	IC₅₀	0.034 μM Compound: 8	Antiproliferative activity against human taxol resistant CCRF-CEM cell line Antiproliferative activity against human taxol resistant CCRF-CEM cell line	[PMID: 16759114]
CCRF-CEM	IC₅₀	12.8 nM Compound: 6, BO-0742	Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay	[PMID: 18450456]
CCRF-CEM	IC₅₀	3.2 nM Compound: 6, BO-0742	Cytotoxicity against taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay Cytotoxicity against taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay	[PMID: 18450456]
CCRF-CEM	IC₅₀	3.33 nM Compound: 6, BO-0742	Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay	[PMID: 18450456]
HCT-116	IC₅₀	0.0055 μM Compound: 6, BO-0742	Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay	[PMID: 19124250]
HCT-116	IC₅₀	0.0055 μM Compound: 8	Antiproliferative activity against human HCT116 cell line Antiproliferative activity against human HCT116 cell line	[PMID: 16759114]
HCT-116	IC₅₀	0.0055 μM Compound: 9	Concentration required for growth inhibition of human HCT116 colon tumor cell line (CCRF-CEM) was determined Concentration required for growth inhibition of human HCT116 colon tumor cell line (CCRF-CEM) was determined	[PMID: 15324894]
HCT-116	IC₅₀	6.5 nM Compound: 6, BO-0742	Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay	[PMID: 18450456]
MX1	IC₅₀	0.0035 μM Compound: 6, BO-0742	Cytotoxicity against human MX1 cells after 72 hrs by SRB assay Cytotoxicity against human MX1 cells after 72 hrs by SRB assay	[PMID: 19124250]
MX1	IC₅₀	0.0035 μM Compound: 8	Antiproliferative activity against human MX1 cell line Antiproliferative activity against human MX1 cell line	[PMID: 16759114]
MX1	IC₅₀	3.5 nM Compound: 6, BO-0742	Cytotoxicity against human MX1 cells after 72 hrs by SRB assay Cytotoxicity against human MX1 cells after 72 hrs by SRB assay	[PMID: 18450456]

Chemical Information

CAS No. 774234-08-1
Masse moléculaire 484.42
Formule C₂₆H₂₇Cl₂N₃O₂
SMILES

OCC1=CC(OCCN(CCCl)CCCl)=CC(NC2=C3C=CC=CC3=NC4=CC=CC=C42)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chien-Hsin Lee, et al. BO-0742, a derivative of AHMA and N-mustard, has selective toxicity to drug sensitive and drug resistant leukemia cells and solid tumors. Cancer Lett. 2009 Apr 18;276(2):204-11. [Content Brief]

Calculators

Calculateur de molarité

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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