BTL-MK
BTL-MK (Compound 19) an orally active antiallergic agent, that inhibits degranulation of mast cells with an IC50 of 6.7 μM, through binding to the inhibitory receptor FcγRIIB. BTL-MK improves the metaboilic stability in human liver microsomes. BTL-MK ameliorates the allergic response in Ovalbumin, low endotoxin (HY-W250978A)-induced food allergy mice model. BTL-MK exhibits a good pharmacokinetic character with metabolic stability.
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- CAS No.: 2758569-43-4
- Formule: C24H24O6
- Masse moléculaire:408.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
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| RBL-2H3 | IC50 |
6.7 μM
Compound: 19; BTL-MK
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Antiallergic activity in rat RBL-2H3 cell model assessed as inhibition rate of IgE-mediated degranulation in by measuring beta-aminosidase
Antiallergic activity in rat RBL-2H3 cell model assessed as inhibition rate of IgE-mediated degranulation in by measuring beta-aminosidase
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[PMID: 38640354] |
Chemical Information
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CAS No. 2758569-43-4
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Masse moléculaire 408.44
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Formule C24H24O6
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SMILES
OC1=CC=C(C=C1C/C=C(C)\C)C[C@]2(OC(C(O)=C2C3=CC=C(C=C3)O)=O)C(C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BTL-MK Related Classifications
HY-158316 Related Classifications
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