Ceefourin 2
Based on 1 Customer Validation
Ceefourin 2 is a potent and highly selective inhibitor of MRP4. Ceefourin 2 inhibits the transport of MRP4 substrates but is not selective for other ABC transporters. Ceefourin 2 shows lower cytotoxicity and higher microsomal and acid stability.
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- Pureté : 98.47%
- CAS No.: 348148-51-6
- Formule: C15H9ClF3N3O2
- Masse moléculaire:355.70
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
Ceefourin 2 is highly selective for MRP4 over other ABC transporters, including P-glycoprotein (P-gp), ABCG2 (Breast Cancer Resistance Protein; BCRP) and MRP1 (ABCC1). Ceefourin 2 has limited off-target effects and high stability[1]. Ceefourin 2 (100 nM-100 μM) has low cellular toxicity (IC50 >50 μM) in two normal (HSF, MRC5), five neuroblastoma (BE(2)-C, IMR-32, IMR-32, SK-N-SH, SHEP) and four other human cancer cell lines (HEPG2, LNCap, SJ-G2, MCF7)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 348148-51-6
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Appearance Solid
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Masse moléculaire 355.70
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Formule C15H9ClF3N3O2
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Color Light yellow to brown
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SMILES
O=C(O)C1=NN2C(C(F)(F)F)=CC(C3=CC=C(C=C3)C)=NC2=C1Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 10 mg/mL (28.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8114 mL | 14.0568 mL | 28.1136 mL | 70.2839 mL |
| 5 mM | 0.5623 mL | 2.8114 mL | 5.6227 mL | 14.0568 mL | |
| 10 mM | 0.2811 mL | 1.4057 mL | 2.8114 mL | 7.0284 mL | |
| 15 mM | 0.1874 mL | 0.9371 mL | 1.8742 mL | 4.6856 mL | |
| 20 mM | 0.1406 mL | 0.7028 mL | 1.4057 mL | 3.5142 mL | |
| 25 mM | 0.1125 mL | 0.5623 mL | 1.1245 mL | 2.8114 mL |
Ceefourin 2 Related Classifications
HY-121088 Related Classifications
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