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Cat. No.: HY-177269

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CHNQD-01269

CHNQD-01269, a brefeldin A-cinnamate derivative, is an Arf1 inhibitor. CHNQD-01269 exhibits potent cytotoxic activity against HepG2 and BEL-7402 cells, with IC₅₀ values of 0.29 and 0.84 μM, respectively. CHNQD-01269 is indicated for hepatocellular carcinoma (HCC) research.

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CAS No.: 2648988-92-3
Formule: C₂₇H₃₅NO₅
Masse moléculaire:453.57

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CHNQD-01269 Chemical Structure

CAS No.: 2648988-92-3

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
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Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Bel-7402	IC₅₀	0.84 μM Compound: 33; CHNQD-01269	Antiproliferative activity against human Bel-7402 cells measured after 72 hrs by MTT assay Antiproliferative activity against human Bel-7402 cells measured after 72 hrs by MTT assay	[PMID: 35849940]
HeLa	IC₅₀	0.86 μM Compound: 33; CHNQD-01269	Antiproliferative activity against human HeLa cells measured after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells measured after 72 hrs by MTT assay	[PMID: 35849940]
HepG2	IC₅₀	0.29 μM Compound: 33; CHNQD-01269	Antiproliferative activity against human HepG2 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells measured after 72 hrs by MTT assay	[PMID: 35849940]
L02	IC₅₀	2.81 μM Compound: 33; CHNQD-01269	Cytotoxicity against human L02 cells measured after 72 hrs by MTT assay Cytotoxicity against human L02 cells measured after 72 hrs by MTT assay	[PMID: 35849940]
PANC-1	IC₅₀	0.64 μM Compound: 33; CHNQD-01269	Antiproliferative activity against human PANC-1 cells measured after 72 hrs by MTT assay Antiproliferative activity against human PANC-1 cells measured after 72 hrs by MTT assay	[PMID: 35849940]

Chemical Information

CAS No. 2648988-92-3
Masse moléculaire 453.57
Formule C₂₇H₃₅NO₅
SMILES

CN(C)C(C=C1)=CC=C1/C=C/C(O[C@H]2[C@@]3([H])[C@@](/C=C/CCC[C@@H](OC(/C=C/2)=O)C)([H])C[C@@H](C3)O)=O
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Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Jiang YY, et al. New brefeldin A-cinnamic acid ester derivatives as potential antitumor agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Oct 5;240:114598. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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