CS-526
CS-526 is a potent, selective, reversible and orally active acid pump antagonist. CS-526 inhibits H+,K+-ATPase activity. CS-526 inhibits gastric acid secretion and prevents esophageal lesions. CS-526 has the potential for the research of gastroesophageal reflux disease.
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- CAS No.: 313272-12-7
- Formule: C20H22FN3O
- Masse moléculaire:339.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
CS-526 (0-100 µM; 60 min) inhibits H+, K+-ATPase and Na+, K+-ATPase activity in a dose-dependent manner with IC50 values of 61 nM, 10.4 µM, respectively[1].
CS-526 competitive binds to K+ binding site of H+, K+-ATPase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CS-526 (1, 3, 10, 30 mg/kg; intrapouch; 180 min) dose-dependently inhibits the histamine-induced gastric acid secretion in the Heidenhain pouch dogs[1].
CS-526 (1, 3, 10, 30 mg/kg; intraduodenal or p.o.) prevents esophageal lesions and acute gastric mucosal lesions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Pylorus-Ligated Rats[1]
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Dosage:1, 3, 10, 30 mg/kg
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Administration:Intraduodenal administration or p.o.
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Result:Dose-dependently inhibited gastric acid secretion with ID50 values of 2.8, 0.7 mg/kg for intraduodenal administration and oral administration, respectively.
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Animal Model:Reflux Esophagitis Model in Rats[1]
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Dosage:1, 3, 10 mg/kg
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Administration:Intraduodenal administration or p.o.
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Result:Significantly reduced the lesion scores with ID50 values of 5.4, 1.9 mg/kg for intraduodenal and p.o. respectively.
Chemical Information
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CAS No. 313272-12-7
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Masse moléculaire 339.41
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Formule C20H22FN3O
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SMILES
C[C@@H]1[C@@H](CN2C(C)=C(C)C3=C2C(OCC4=CC=C(F)C=C4)=NN=C3)C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CS-526 Related Classifications
HY-100413 Related Classifications
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