country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-169013

Copy Link Print Information

DDO-3733

DDO-3733 is a TRP-independent Protein Phosphatase 5 (PP5) allosteric activator that promotes dephosphorylation of downstream substrates.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2923531-63-7
Formule: C₁₀H₆F₂N₂OS
Masse moléculaire:240.23

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

DDO-3733 Chemical Structure

CAS No.: 2923531-63-7

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

DDO-3733 is a TRP-independent Protein Phosphatase 5 (PP5) allosteric activator that promotes dephosphorylation of downstream substrates^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	40.79 nM Compound: P5-22; DDO-3733	Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human HCT-116 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 78.49 nM) Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human HCT-116 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 78.49 nM)	[PMID: 39145509]
SW-620	IC₅₀	54.41 nM Compound: P5-22; DDO-3733	Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human SW620 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 122.3 nM) Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human SW620 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 122.3 nM)	[PMID: 39145509]

Chemical Information

CAS No. 2923531-63-7
Masse moléculaire 240.23
Formule C₁₀H₆F₂N₂OS
SMILES

S=C(C1=CC2=C(F)C=C(F)C=C2OC1=N)N
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhang Q, et al. Allosteric Activation of Protein Phosphatase 5 with Small Molecules. J Med Chem. 2024 Sep 12;67(17):15080-15097. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Obtenir un devis En stock