Dicatenarin
Dicatenarin is a caspase‑3 activator with growth‑inhibitory activity against human cancer cells. Dicatenarin increases caspase‑3 activity, induces intracellular ROS generation, and activates the mitochondrial‑mediated apoptotic pathway. Dicatenarin exerts growth‑inhibitory effects against a panel of human cancer cell lines. Dicatenarin can be used in research on pancreatic cancer, lung cancer, colon cancer, breast cancer, prostate cancer, and ovarian cancer.
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- CAS No.: 1065-08-3
- Formule: C30H18O12
- Masse moléculaire:570.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
IC50 & Target
[1]|
Caspase-3 |
In Vitro
Dicatenarin (1-100 µg/mL; 48 h) potently inhibits growth of human lung (A549), pancreatic (MIA PaCa-2), colon (HCT-116), breast (T47D), prostate (PC-3), and ovarian (OVCAR-3) cancer cell lines in vitro, with the lowest IC50 of 12 µg/mL against MIA PaCa-2 cells[1][2].
induces both early and late-stage apoptosisDicatenarin (5-20 µg/mL; 48 h) induces concentration-dependent apoptotic nuclear morphological changes in human pancreatic cancer (MIA PaCa-2) cells[1].
Dicatenarin (20 µg/mL; 48 h) induces both early and late-stage apoptosis in human pancreatic cancer (MIA PaCa-2) cells[1].
Dicatenarin (5-20 µg/mL; 48 h) induces concentration-dependent intracellular ROS generation in human pancreatic cancer (MIA PaCa-2) cells[1].
Dicatenarin (5-20 µg/mL; 48 h) induces concentration-dependent loss of mitochondrial transmembrane potential in human pancreatic cancer (MIA PaCa-2) cells[1].
Dicatenarin (5-20 µg/mL; 48 h) induces concentration-dependent release of cytochrome c from mitochondria to the cytosol in human pancreatic cancer (MIA PaCa-2) cells[1].
Dicatenarin (5-20 µg/mL; 48 h) induces concentration-dependent activation of caspase-3 in human pancreatic cancer (MIA PaCa-2) cells[1].
Dicatenarin (5-20 µg/mL; 7 days) potently inhibits clonogenic survival of human pancreatic cancer (MIA PaCa-2) cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, MIA PaCa-2, HCT-116, T47D, PC-3, OVCAR-3
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Concentration:1, 10, 30, 50, 100 µg/mL
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Incubation Time:48 h
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Result:Exhibited cytotoxicity against all tested cell lines, with IC50 values of 23 µg/mL (A549), 12 µg/mL (MIA PaCa-2), 17 µg/mL (HCT-116), 29 µg/mL (T47D), 35 µg/mL (PC-3), and 26 µg/mL (OVCAR-3).
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Cell Line:MIA PaCa-2
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Concentration:20 µg/mL
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Incubation Time:48 h
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Result:Resulted in significant phosphatidylserine externalization (early apoptosis) and late-stage apoptotic/necrotic PI-positive staining, with a higher proportion of annexin V-positive cells compared to skyrin treatment.
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Cell Line:MIA PaCa-2
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Concentration:5, 10, 20 µg/mL
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Incubation Time:48 h
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Result:Induced concentration-dependent release of cytochrome c from mitochondria into the cytosol.
Showed minimal release at 5 µg/mL, moderate release at 10 µg/mL, prominent, diffuse cytosolic cytochrome c staining at 20 µg/mL, indicating complete mitochondrial outer membrane permeabilization.
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Cell Line:MIA PaCa-2
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Concentration:5, 10, 20 µg/mL
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Incubation Time:7 days
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Result:Caused concentration-dependent inhibition of colony formation.
Reduced colony number to ~460 (from ~550 in controls) at 5 µg/mL, to ~210 at 10 µg/mL, to ~50 at 20 µg/mL, representing a 91% reduction in colony formation at the highest concentration.
Chemical Information
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CAS No. 1065-08-3
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Masse moléculaire 570.46
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Formule C30H18O12
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SMILES
O=C1C2=C(C=C(C)C(O)=C2C(C3=C1C(O)=CC(O)=C3C(C(O)=CC(O)=C4C(C5=C(C=C(C)C(O)=C56)O)=O)=C4C6=O)=O)O
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Structure Classification
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Initial Source
Penicillium pinophilum
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dicatenarin Related Classifications
HY-N19463 Related Classifications
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