DU-14
Based on 1 Customer Validation
DU-14 is a potent steroid sulfatase inhibitor with an IC50 of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC50 = 38.7 nM). DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity.
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- Pureté : 98.08%
- CAS No.: 186303-55-9
- Formule: C22H38N2O4S
- Masse moléculaire:426.61
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
DU-14 (0.001-10 μM, 18 h) inhibits estrone sulfatase activity in MDA-MB-23l cell, with an IC50 of 350 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Neurotoxicity Study
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Protocol for Water Maze
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Cell Viability Determination by MTT Colorimetric Assay
- Alzheimer’s Disease Modeling
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- MTT Cell Proliferation Assay
Chemical Information
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CAS No. 186303-55-9
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Appearance Solid
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Masse moléculaire 426.61
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Formule C22H38N2O4S
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Color White to off-white
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SMILES
CCCCCCCCCCCCCC(NCCC1=CC=C(C=C1)OS(N)(=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 125 mg/mL (293.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Selcer KW, et al. Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyramines. Cancer Res. 1997 Feb 15;57(4):702-7. [Content Brief]
[2]. Li PK, et al. Memory enhancement mediated by the steroid sulfatase inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine. Life Sci. 1997;60(3):PL45-51. [Content Brief]
[3]. Yue XH, et al. Steroid sulfatase inhibitor DU-14 protects spatial memory and synaptic plasticity from disruption by amyloid β protein in male rats. Horm Behav. 2016 Jul;83:83-92. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3441 mL | 11.7203 mL | 23.4406 mL | 58.6015 mL |
| 5 mM | 0.4688 mL | 2.3441 mL | 4.6881 mL | 11.7203 mL | |
| 10 mM | 0.2344 mL | 1.1720 mL | 2.3441 mL | 5.8602 mL | |
| 15 mM | 0.1563 mL | 0.7814 mL | 1.5627 mL | 3.9068 mL | |
| 20 mM | 0.1172 mL | 0.5860 mL | 1.1720 mL | 2.9301 mL | |
| 25 mM | 0.0938 mL | 0.4688 mL | 0.9376 mL | 2.3441 mL | |
| 30 mM | 0.0781 mL | 0.3907 mL | 0.7814 mL | 1.9534 mL | |
| 40 mM | 0.0586 mL | 0.2930 mL | 0.5860 mL | 1.4650 mL | |
| 50 mM | 0.0469 mL | 0.2344 mL | 0.4688 mL | 1.1720 mL | |
| 60 mM | 0.0391 mL | 0.1953 mL | 0.3907 mL | 0.9767 mL | |
| 80 mM | 0.0293 mL | 0.1465 mL | 0.2930 mL | 0.7325 mL | |
| 100 mM | 0.0234 mL | 0.1172 mL | 0.2344 mL | 0.5860 mL |
DU-14 Related Classifications
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