ER-67880
ER-67880 is a potent microtubule inhibitor with an IC50 of 9.5 μM. ER-67880 exhibits anti-proliferative activity against KB, Colon 38 and P338 cells with IC50s of 0.55, 0.2 and 0.76 μg/mL. ER-67880 causes G2/M phase arrest and is accompanied by abnormal DNA replication. ER-67880 exhibits a down-regulation pattern of G1 phase-related genes. ER-67880 can be used in various cancer studies, including those of nasopharyngeal carcinoma and murine adenocarcinoma.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 247186-96-5
- Formule: C15H13ClN2O3S
- Masse moléculaire:336.79
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.37 μM
Compound: 5
|
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 cell line
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 cell line
|
[PMID: 12383017] |
| HCT-116 | IC50 |
2.2 μM
Compound: 5
|
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 -C1cell line
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 -C1cell line
|
[PMID: 12383017] |
| KB | IC50 |
0.55 μg/mL
Compound: 16
|
Antiproliferative activity against KB human nasopharynx carcinoma in vitro
Antiproliferative activity against KB human nasopharynx carcinoma in vitro
|
[PMID: 10508428] |
| KB | IC50 |
0.55 μg/mL
Compound: 3
|
In vitro antiproliferative activity (4 ug/mL) was measured against KB cancer cell line using MTT colorimetric assay
In vitro antiproliferative activity (4 ug/mL) was measured against KB cancer cell line using MTT colorimetric assay
|
[PMID: 10866386] |
| MC-38 | IC50 |
0.2 μg/mL
Compound: 16
|
In vitro antiproliferative activity against colon 38 murine adenocarcinoma
In vitro antiproliferative activity against colon 38 murine adenocarcinoma
|
[PMID: 10508428] |
| MC-38 | IC50 |
0.2 μg/mL
Compound: 3
|
In vitro antiproliferative activity (4 ug/mL) was measured against colon 38 cancer cell line using MTT colorimetric assay
In vitro antiproliferative activity (4 ug/mL) was measured against colon 38 cancer cell line using MTT colorimetric assay
|
[PMID: 10866386] |
| P388 | IC50 |
0.76 μg/mL
Compound: 16
|
Antiproliferative activity against P388 murine leukemia in vitro
Antiproliferative activity against P388 murine leukemia in vitro
|
[PMID: 10508428] |
| P388 | IC50 |
0.76 μg/mL
Compound: 3
|
In vitro antiproliferative activity (4 ug/mL) was measured against P388 cancer cell line using MTT colorimetric assay
In vitro antiproliferative activity (4 ug/mL) was measured against P388 cancer cell line using MTT colorimetric assay
|
[PMID: 10866386] |
| P388 | IC50 |
1.2 μM
Compound: 5
|
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388 cell line
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388 cell line
|
[PMID: 12383017] |
| P388 | IC50 |
1.2 μM
Compound: 5
|
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388/4.0 r-M cell line
Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388/4.0 r-M cell line
|
[PMID: 12383017] |
Chemical Information
-
CAS No. 247186-96-5
-
Masse moléculaire 336.79
-
Formule C15H13ClN2O3S
-
SMILES
O=S(C1=CC=C(C=C1)OC)(NC2=CC=CC3=C2NC=C3Cl)=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ER-67880 Related Classifications
HY-118385 Related Classifications
Powered by Bioz