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Cat. No.: HY-155529

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FD1024

FD1024 is PIM inhibitor (IC₅₀s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3). FD1024 can be used for research of acute myeloid leukemia. FD1024 has strong antiproliferative activity against the tested AML cell lines, with 0.16 μM, 0.12 μM, 1.05 μM, 1.39μM for EOL-1, MV-4-11, KG-1, MOLM-16 cells. FD1024 also has antitumor efficacy in mice.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1422456-47-0
Formule: C₂₁H₂₀F₂N₄O₂S
Masse moléculaire:430.47

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

FD1024 Chemical Structure

CAS No.: 1422456-47-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

1.96, 38.9, 4.17 nM for PIM1, 2, 3^[1]

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Cellular Effect

Cell Line	Type	Value	Description	References
EOL1	IC₅₀	0.16 μM Compound: 24	Antiproliferative activity against human EOL1 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Antiproliferative activity against human EOL1 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 37262997]
KG-1	IC₅₀	1.05 μM Compound: 24	Antiproliferative activity against human KG-1 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Antiproliferative activity against human KG-1 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 37262997]
MOLM-16	IC₅₀	1.39 μM Compound: 24	Antiproliferative activity against human MOLM16 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Antiproliferative activity against human MOLM16 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 37262997]
MV4-11	IC₅₀	0.12 μM Compound: 24	Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 37262997]

Chemical Information

CAS No. 1422456-47-0
Masse moléculaire 430.47
Formule C₂₁H₂₀F₂N₄O₂S
SMILES

O=C(C1=CSC(C2=C(F)C=CC=C2F)=N1)NC3=C(O[C@H]4CC[C@H](N)CC4)C=CN=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Xiang R, et al. Discovery of a high potent PIM kinase inhibitor for acute myeloid leukemia based on N-pyridinyl amide scaffold by optimizing the fragments toward to Lys67 and Asp128/Glu171. Eur J Med Chem. 2023 Sep 5;257:115514. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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FD1024

Voir tous les produits spécifiques à Isoform Pim

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

FD1024 Related Classifications

HY-155529 Related Classifications