(-)-Folicanthine
(-)-Folicanthine is a dimeric tryptamine-related alkaloid found in the fruits of Chimonanthus praecox. (-)-Folicanthine shows cytotoxic against cancer cells. (-)-Folicanthine can be used for the research of cancer, such as gastric carcinoma and hepatocarcinoma.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 6879-55-6
- Formule: C24H30N4
- Masse moléculaire:374.52
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
In Vitro
(-)-Folicanthine (Compound 12) (72 h) exhibits cytotoxic activity against human gastric carcinoma NUGC3 cells, human hepatocarcinoma SNU739 cells, and human neuroblastoma SHSY-5Y cells, with IC50 values of 13.3 ± 1.5 μM, 17.0 ± 2.8 μM, and 60.1 ± 3.5 μM respectively, and shows no significant cytotoxicity against human breast cancer MCF-7 cells (IC50 >100 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
-
Cell Line:human gastric carcinoma NUGC3 cells, human hepatocarcinoma SNU739 cells, human neuroblastoma SHSY-5Y cells, human breast cancer MCF-7 cells
-
Concentration:0-100 μM
-
Incubation Time:72 h
-
Result:Exhibited cytotoxic activity with an IC50 of 13.3 ± 1.5 μM against NUGC3 cells.
Exhibited cytotoxic activity with an IC50 of 17.0 ± 2.8 μM against SNU739 cells.
Exhibited cytotoxic activity with an IC50 of 60.1 ± 3.5 μM against SHSY-5Y cells.
Showed no significant cytotoxicity against MCF-7 cells with an IC50 >100 μM.
Chemical Information
-
CAS No. 6879-55-6
-
Masse moléculaire 374.52
-
Formule C24H30N4
-
SMILES
CN1[C@]2([H])[C@](CCN2C)([C@@]34[C@@](N(CC4)C)([H])N(C5=CC=CC=C53)C)C6=CC=CC=C61
-
Structure Classification
-
Initial Source
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
-
Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(-)-Folicanthine Related Classifications
HY-N17973 Related Classifications
Powered by Bioz