RAMP2 - receptor activity modifying protein 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10266

About RAMP2

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,761,227-42,763,041 (from NCBI)

This gene has 6 transcripts (splice variants), 198 orthologues and 2 paralogues. Broad expression in lung (RPKM 58.9), fat (RPKM 57.7) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (Calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an Adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an Adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of Adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]

RAMP2 Products (1)

mRNA Protein Name
NM_005854.3 NP_005845.2 receptor activity-modifying protein 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables adrenomedullin binding IPI
IPI: Inferred from physical interaction
22102369 GOA
enables adrenomedullin receptor activity IPI
IPI: Inferred from physical interaction
9620797 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9620797 GOA
Biological Process GO Annotation Evidence Références Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IPI
IPI: Inferred from physical interaction
9620797 GOA
involved in adherens junction assembly IDA
IDA: Inferred from direct assay
18097473 GOA
involved in adrenomedullin receptor signaling pathway IPI
IPI: Inferred from physical interaction
9620797 GOA
involved in angiogenesis IDA
IDA: Inferred from direct assay
20596610 GOA
involved in bicellular tight junction assembly IDA
IDA: Inferred from direct assay
18097473 GOA
involved in calcium ion transport IDA
IDA: Inferred from direct assay
10882736 GOA
involved in negative regulation of endothelial cell apoptotic process IDA
IDA: Inferred from direct assay
18097473 GOA
involved in negative regulation of vascular permeability IDA
IDA: Inferred from direct assay
18097473 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
18097473 GOA
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
10882736 GOA
involved in protein transport IDA
IDA: Inferred from direct assay
9620797 GOA
involved in receptor internalization IDA
IDA: Inferred from direct assay
10882736 GOA
involved in vasculogenesis IMP
IMP: Inferred from mutant phenotype
16964401 GOA
Cellular Component GO Annotation Evidence Références Source
part of adrenomedullin receptor complex IDA
IDA: Inferred from direct assay
9620797 GOA
located in cell surface IDA
IDA: Inferred from direct assay
14722252 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
10882736 GOA
colocalizes with plasma membrane IDA
IDA: Inferred from direct assay
9620797 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
15613468 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAMP2 Protein Structure

RAMP

RAMP: Receptor activity modifying family (65 - 174)

  • 0
  • 100
  • 175 a.a.
Protein Preferred Names Protein Names

receptor activity-modifying protein 2

  • CRLR activity-modifying protein 2

RAMP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
RAMP2 O60895 LCN2 Homo sapiens P80188
Y2H Array
32296183
Intra
RAMP2 O60895 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
Intra
RAMP2 O60895 LCN2 Homo sapiens P80188
Validated Y2H
32296183
Intra
RAMP2 O60895 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra
RAMP2 O60895 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra
RAMP2 O60895 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra
RAMP2 O60895 CALCRL Homo sapiens Q16602
Crosslink
22102369
Intra
RAMP2 O60895 CALCRL Homo sapiens Q16602
X-Ray Diffraction
22102369
Intra
RAMP2 O60895 CALCRL Homo sapiens Q16602
Anti Tag CoIP
22102369
Intra
RAMP2 O60895 CALCRL Homo sapiens Q16602
GMS
22102369
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pheochromocytoma

  • Pheochromocytoma, Susceptibility To

  • Phaeochromocytoma

  • Adrenal Gland Chromaffin Paraganglioma

  • Adrenal Gland Chromaffinoma

  • Adrenal Gland Paraganglioma

  • Adrenal Gland Pheochromocytoma

  • Chromaffin Paraganglioma Of The Adrenal Gland

  • Intraadrenal Paraganglioma

  • PCC

  • Chromaffin Cell Tumor

  • Medullary Chromaffinoma

  • Medullary Paraganglioma

  • Pheochromoblastoma

  • Pheochromocytomas

  • Chromaffin Cell Neoplasm

  • Pheochromocytoma, Malignant
Cartilage Cancer

  • Chondrogenic Neoplasm
Lutembacher'S Syndrome

  • Lutembacher Syndrome

  • Lutembacher'S Anomaly
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P1548 β-CGRP, human 99.36% Unkown
HY-P1548A β-CGRP, human TFA 99.57% Unkown
HY-P1548B β-CGRP, human acetate / Unkown
HY-RS11639 RAMP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183142 CLR/RAMP3-receptor antagonist-1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RAMP2 VGNC VGNC:69231
Macaca mulatta RAMP2 VGNC VGNC:76653
Mus musculus RAMP2 MGD MGI:1859650
Bos taurus RAMP2 VGNC VGNC:33707
Rattus norvegicus RAMP2 RGD RGD:61872
Others RAMP2 NCBI