CSF3 - colony stimulating factor 3 Gene
Also Known as GCSF; CSF3OS; C17orf33
Species: Homo sapiens
About CSF3
This gene has 9 transcripts (splice variants) and 242 orthologues. Biased expression in appendix (RPKM 6.9), urinary bladder (RPKM 3.3) and 8 other tissues.
Summary
This gene encodes a member of the IL-6 superfamily of cytokines. The encoded cytokine controls the production, differentiation, and function of granulocytes. Granulocytes are a type of white blood cell that are part of the innate immune response. A modified form of this protein is commonly administered to manage chemotherapy-induced neutropenia. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2020]
CSF3 Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_000759.4 | NP_000750.1 | granulocyte colony-stimulating factor isoform a precursor |
| NM_001178147.2 | NP_001171618.1 | granulocyte colony-stimulating factor isoform d precursor |
| NM_172219.3 | NP_757373.1 | granulocyte colony-stimulating factor isoform b precursor |
| NM_172220.3 | NP_757374.2 | granulocyte colony-stimulating factor isoform c precursor |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables cytokine activity |
IDA
IDA: Inferred from direct assay
|
23001182 | GOA |
| enables enzyme binding |
IPI
IPI: Inferred from physical interaction
|
12393522 | GOA |
| Biological Process GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| involved in cellular response to cytokine stimulus |
IDA
IDA: Inferred from direct assay
|
23001182 | GOA |
| involved in granulocyte colony-stimulating factor signaling pathway |
IDA
IDA: Inferred from direct assay
|
23001182 | GOA |
| involved in positive regulation of actin filament polymerization |
IDA
IDA: Inferred from direct assay
|
23001182 | GOA |
| involved in positive regulation of peptidyl-tyrosine phosphorylation |
IDA
IDA: Inferred from direct assay
|
23001182 | GOA |
| involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
IDA
IDA: Inferred from direct assay
|
23001182 | GOA |
| involved in positive regulation of transcription by RNA polymerase II |
IDA
IDA: Inferred from direct assay
|
23001182 | GOA |
| involved in regulation of actin filament organization |
IDA
IDA: Inferred from direct assay
|
23001182 | GOA |
CSF3 Protein Structure
IL6: Interleukin-6/G-CSF/MGF family (51 - 202)
- 0
- 100
- 207 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
granulocyte colony-stimulating factor |
|
Recombinant CSF3 Proteins
| Cat. No. | Nom du produit | Accession | Pureté |
|---|---|---|---|
| HY-P7015A | G-CSF Protein, Human (CHO) | Q8N4W3 (T27-P200)/P09919-2 (T31-P204) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70422 | G-CSF Protein, Human | Q8N4W3 (T27-P200)/P09919-2 (T31-P204) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73073 | G-CSF Protein, Human (HEK293, Fc) | P09919-2/NP_757373.1 (T31-P204) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700083AF | Animal-Free G-CSF Protein, Human (His) | P09919-2 (T31-P204) | ≥ 95%, as determined by reducing SDS-PAGE. |
CSF3 Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P83562 | G-CSF Antibody (YA3307) | WB, ICC/IF, IP | Human, Mouse, Rat |
| HY-P86710 | G-CSF Antibody (YA6402) | WB, IHC-P, IHC-F, IF-Tissue | Human, Mouse |
| HY-P86710A | G-CSF Antibody (YA6402)(PBS only) | WB, IHC-P, IHC-F, IF-Tissue | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Neutropenia |
|
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| Mucositis |
|
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| Granulocytopenia |
|
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| Cyclic Neutropenia |
|
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| Felty Syndrome |
|
|
| Severe Congenital Neutropenia |
|
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| Acute Graft Versus Host Disease |
|
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| Neutrophilic Dermatosis, Acute Febrile |
|
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| Chronic Neutrophilic Leukemia |
|
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| Neutrophilia, Hereditary |
|
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| Paraneoplastic Syndromes |
|
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| Pancytopenia |
|
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| Hematologic Cancer |
|
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| Aplastic Anemia |
|
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| Refractory Anemia |
|
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| Pneumonia |
|
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| Mucormycosis |
|
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| Neutropenia, Severe Congenital, 3, Autosomal Recessive |
|
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| Paroxysmal Nocturnal Hemoglobinuria |
|
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| Bacterial Pneumonia |
|
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| Thrombocytosis |
|
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| Acute Leukemia |
|
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| Graft-Versus-Host Disease |
|
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| Aseptic Meningitis |
|
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| Pyoderma |
|
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| Pyoderma Gangrenosum |
|
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| Poems Syndrome |
|
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| Bacterial Infectious Disease |
|
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| Hypersplenism |
|
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| Hepatic Veno-Occlusive Disease |
|
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| Hemorrhagic Cystitis |
|
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| Glycogen Storage Disease |
|
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| Chronic Eosinophilic Pneumonia |
|
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| Aspergillosis |
|
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| Chronic Graft Versus Host Disease |
|
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| Hemoglobinuria |
|
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| Eosinophilic Gastroenteritis |
|
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| Myelodysplastic Syndrome |
|
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| Meconium Aspiration Syndrome |
|
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| Appendicitis |
|
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| Panniculitis |
|
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| Melioidosis |
|
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| Macroglossia |
|
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| Thrombocytopenia |
|
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| Myelofibrosis |
|
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| Acute Promyelocytic Leukemia |
|
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| Lymphoma, Hodgkin, Classic |
|
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| Lymphoma, Non-Hodgkin, Familial |
|
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| Myeloid Leukemia |
|
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| Cryptosporidiosis |
|
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| Pulmonary Edema |
|
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| Leukocyte Disease |
|
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| Stomatitis |
|
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| Inflammatory Breast Carcinoma |
|
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| Leukemia, Chronic Myeloid |
|
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| Smallpox |
|
|
| Diamond-Blackfan Anemia 14 With Mandibulofacial Dysostosis |
|
|
| Ecthyma |
|
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| Deficiency Anemia |
|
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| Pyelonephritis |
|
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| Combined Immunodeficiency |
|
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| Gingivitis |
|
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| Meningitis |
|
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| Osteomyelitis |
|
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| Gastroenteritis |
|
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| Fusariosis |
|
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| Bacterial Meningitis |
|
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| Lymphoma |
|
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| Severe Congenital Neutropenia 3 |
|
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| Ovarian Clear Cell Cystadenocarcinoma |
|
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| Fallopian Tube Mucinous Adenocarcinoma |
|
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| Mixed Epithelial Tumor Of Ovary |
|
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| Ovarian Clear Cell Malignant Adenofibroma |
|
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| Fallopian Tube Transitional Cell Carcinoma |
|
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| Trypanosomiasis |
|
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| Diarrhea |
|
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| Candidiasis |
|
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| Essential Thrombocythemia |
|
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| Lung Cancer |
|
|
| Chronic Myelomonocytic Leukemia |
|
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| Brain Edema |
|
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| Monocytic Leukemia |
|
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| Polycythemia Vera |
|
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| Myeloproliferative Neoplasm |
|
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| Thymus Small Cell Carcinoma |
|
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| Toxic Shock Syndrome |
|
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| Peritonitis |
|
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| Leukocyte Adhesion Deficiency, Type I |
|
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| Leukemia, Acute Lymphoblastic |
|
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| Otitis Media |
|
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| Hodgkin'S Paragranuloma |
|
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| Whim Syndrome 1 |
|
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| Pneumocystosis |
|
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| Thymoma |
|
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| Blau Syndrome |
|
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| Severe Combined Immunodeficiency |
|
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| Blood Coagulation Disease |
|
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| Buerger Disease |
|
|
| Burkitt Lymphoma |
|
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| Leukemia, Acute Myeloid |
|
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| Ovarian Cancer |
|
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| Malaria |
|
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| Hair Disease |
|
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| Blood Platelet Disease |
|
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| Aortitis |
|
|
| Myeloma, Multiple |
|
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| Severe Covid-19 |
|
|
| Cerebral Palsy |
|
|
| Opportunistic Mycosis |
|
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| Cellulitis |
|
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| Bacterial Sepsis |
|
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| Bone Marrow Cancer |
|
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| Critical Covid-19 |
|
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| Pure Red-Cell Aplasia |
|
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| Viral Pneumonia |
|
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| Coronavirus Infectious Disease |
|
|
| Fungal Infectious Disease |
|
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| Exanthem |
|
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| Breast Cancer |
|
|
| Hemophagocytic Lymphohistiocytosis |
|
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| Limb Ischemia |
|
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| Glioblastoma |
|
|
| Invasive Aspergillosis |
|
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| Aphthous Stomatitis |
|
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| Chickenpox |
|
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| Capillary Disease |
|
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| Hepatic Vascular Disease |
|
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| Sensory Peripheral Neuropathy |
|
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| Myocardial Infarction |
|
|
| Systemic Lupus Erythematosus |
|
|
| Shwachman-Diamond Syndrome 1 |
|
|
| Respiratory Failure |
|
|
| Fanconi Anemia, Complementation Group A |
|
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| Cystic Fibrosis |
|
|
| Hemoglobinopathy |
|
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| Pancreatic Cancer |
|
|
| Lipoprotein Quantitative Trait Locus |
|
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| Chronic Granulomatous Disease |
|
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| Neuroblastoma |
|
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| Medulloblastoma |
|
|
| Bilirubin Metabolic Disorder |
|
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| Sickle Cell Anemia |
|
|
| Peripheral Nervous System Disease |
|
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| Dyskeratosis Congenita |
|
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| Behcet Syndrome |
|
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| Skin Disease |
|
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| Leukemia, Chronic Lymphocytic |
|
|
| Connective Tissue Disease |
|
|
| Diamond-Blackfan Anemia |
|
|
| Nervous System Disease |
|
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | CSF3 | MGD | MGI:1339751 |
| Felis catus | CSF3 | VGNC | VGNC:98897 |
| Rattus norvegicus | CSF3 | RGD | RGD:2426 |
| Macaca mulatta | CSF3 | VGNC | VGNC:71520 |
| Bos taurus | CSF3 | VGNC | VGNC:27757 |
| Canis familiaris | CSF3 | VGNC | VGNC:39657 |
| Others | CSF3 | NCBI |