CIDEB - cell death inducing DFFA like effector b Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27141

About CIDEB

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,305,187-24,311,435 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 192 orthologues and 3 paralogues. Ubiquitous expression in liver (RPKM 36.3), duodenum (RPKM 31.8) and 24 other tissues.

Summary

Enables identical protein binding activity. Involved in activation of cysteine-type endopeptidase activity; positive regulation of cell death; and positive regulation of release of cytochrome c from mitochondria. Acts upstream of or within apoptotic process. Located in cytosol and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CIDEB Products (9)

mRNA Protein Name
NM_001318807.3 NP_001305736.1 cell death activator CIDE-B isoform 1
NM_001393334.1 NP_001380263.1 cell death activator CIDE-B isoform 1
NM_001393335.1 NP_001380264.1 cell death activator CIDE-B isoform 1
NM_001393336.1 NP_001380265.1 cell death activator CIDE-B isoform 1
NM_001393337.1 NP_001380266.1 cell death activator CIDE-B isoform 1
NM_001393338.1 NP_001380267.1 cell death activator CIDE-B isoform 1
NM_001393339.1 NP_001380268.1 cell death activator CIDE-B isoform 1
NM_001393340.1 NP_001380269.1 cell death activator CIDE-B isoform 2
NM_014430.4 NP_055245.2 cell death activator CIDE-B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
12595532 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12595532 GOA
Biological Process GO Annotation Evidence Références Source
acts upstream of or within apoptotic process IDA
IDA: Inferred from direct assay
12429024 GOA
involved in lipid droplet fusion IMP
IMP: Inferred from mutant phenotype
35939579 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
12595532 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytosol IDA
IDA: Inferred from direct assay
12429024 GOA
is active in lipid droplet IDA
IDA: Inferred from direct assay
35939579 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12595532 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIDEB Protein Structure

CIDE-N

CIDE-N: CIDE-N domain (35 - 110)

  • 0
  • 100
  • 200
  • 219 a.a.
Protein Preferred Names Protein Names

cell death activator CIDE-B

CIDEB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
CIDEB Q9UHD4 NDRG4 Homo sapiens Q9ULP0-2
Validated Y2H
32296183
Intra
CIDEB Q9UHD4 APOC1 Homo sapiens P02654
Y2H Array
32296183
Intra
CIDEB Q9UHD4 APOC1 Homo sapiens P02654
Y2H Prey Pooling
32296183
Intra
CIDEB Q9UHD4 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
Intra
CIDEB Q9UHD4 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
Intra
CIDEB Q9UHD4 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra
CIDEB Q9UHD4 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra
CIDEB Q9UHD4 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra
CIDEB Q9UHD4 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Intra
CIDEB Q9UHD4 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra
CIDEB Q9UHD4 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra
CIDEB Q9UHD4 NAALAD2 Homo sapiens Q9Y3Q0
Validated Y2H
32296183
Intra
CIDEB Q9UHD4 TAOK2 Homo sapiens Q9UL54
Validated Y2H
32296183
Intra
CIDEB Q9UHD4 SAR1B Homo sapiens Q9Y6B6
Validated Y2H
32296183
Intra
CIDEB Q9UHD4 MVB12A Homo sapiens Q96EY5
Anti Tag CoIP
33961781
Intra
CIDEB Q9UHD4 MVB12A Homo sapiens Q96EY5
Anti Tag CoIP
28514442
Intra
CIDEB Q9UHD4 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra
CIDEB Q9UHD4 CIDEB Homo sapiens Q9UHD4
Y2H
12595532
Intra
CIDEB Q9UHD4 CIDEB Homo sapiens Q9UHD4
Pull Down
12595532
Intra
CIDEB Q9UHD4 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra
CIDEB Q9UHD4 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra
CIDEB Q9UHD4 NFU1 Homo sapiens Q9UMS0
Validated Y2H
32296183
Intra
CIDEB Q9UHD4 NME4 Homo sapiens O00746
Y2H Array
32296183
Cross
CIDEB Q9UHD4 P27958-PRO_0000037572 Hepatitis C virus P27958-PRO_0000037572
Y2H
12595532
Cross
CIDEB Q9UHD4 P27958-PRO_0000037572 Hepatitis C virus P27958-PRO_0000037572
Pull Down
12595532
Cross
CIDEB Q9UHD4 P27958-PRO_0000037572 Hepatitis C virus P27958-PRO_0000037572
Confocal
12595532
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS02712 CIDEB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21530 Cideb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28048 Cideb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CIDEB RGD RGD:1310000
Felis catus CIDEB VGNC VGNC:60901
Bos taurus CIDEB VGNC VGNC:27364
Macaca mulatta CIDEB VGNC VGNC:84324
Mus musculus CIDEB MGD MGI:1270844
Others CIDEB NCBI