KRT18 - keratin 18 Gene

Also Known as K18; CK-18; CYK18

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3875

About KRT18

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,948,855-52,952,906 (from NCBI)

This gene has 7 transcripts (splice variants), 253 orthologues, 68 paralogues and is associated with 1 phenotype. Broad expression in placenta (RPKM 258.0), colon (RPKM 230.1) and 15 other tissues.

Summary

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

KRT18 Products (2)

mRNA	Protein	Name
NM_000224.3	NP_000215.1	keratin, type I cytoskeletal 18
NM_199187.2	NP_954657.1	keratin, type I cytoskeletal 18

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10852826	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	10852826	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in Golgi to plasma membrane protein transport	IDA IDA: Inferred from direct assay	15529338	GOA
involved in intermediate filament cytoskeleton organization	IDA IDA: Inferred from direct assay	20346438	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	11684708	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in centriolar satellite	IDA IDA: Inferred from direct assay	18000879	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16424149	GOA
located in intermediate filament	IDA IDA: Inferred from direct assay	10852826	GOA
located in keratin filament	IDA IDA: Inferred from direct assay	16424149	GOA
located in keratin filament	IPI IPI: Inferred from physical interaction	10852826	GOA
located in microtubule organizing center	IDA IDA: Inferred from direct assay	18000879	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT18 Protein Structure

Filament

0
100
200
300
400
430 a.a.

Protein Preferred Names	Protein Names
keratin, type I cytoskeletal 18	cell proliferation-inducing gene 46 protein

KRT18 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	KRT18	P05783	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	KRT18	P05783	CCDC146	Homo sapiens	Q8IYE0-2	Y2H Array	25416956
Intra	KRT18	P05783	DNAJB6	Homo sapiens	O75190	Y2H	10954706
Intra	KRT18	P05783	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	KRT18	P05783	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	KRT18	P05783	KRT79	Homo sapiens	Q5XKE5	Validated Y2H	32296183
Intra	KRT18	P05783	HAUS1	Homo sapiens	Q96CS2	Validated Y2H	25416956
Intra	KRT18	P05783	KRT6C	Homo sapiens	P48668	Validated Y2H	32296183
Intra	KRT18	P05783	KRT6C	Homo sapiens	P48668	Crosslink	30021884
Intra	KRT18	P05783	KRT71	Homo sapiens	Q3SY84	Validated Y2H	32296183
Intra	KRT18	P05783	KRT8	Homo sapiens	P05787	Validated Y2H	32296183
Intra	KRT18	P05783	KRT8	Homo sapiens	P05787	Biophysical	14756564
Intra	KRT18	P05783	KRT8	Homo sapiens	P05787	Solution Sedimentation	10852826
Intra	KRT18	P05783	KRT8	Homo sapiens	P05787	IF	11684708
Intra	KRT18	P05783	KRT8	Homo sapiens	P05787	Confocal	21988832
Intra	KRT18	P05783	KRT8	Homo sapiens	P05787	Cosedimentation	11684708
Intra	KRT18	P05783	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	KRT18	P05783	TRADD	Homo sapiens	Q15628	IF	11684708
Intra	KRT18	P05783	TRADD	Homo sapiens	Q15628	Cosedimentation	11684708
Intra	KRT18	P05783	TRADD	Homo sapiens	Q15628	Y2H	11684708
Intra	KRT18	P05783	TRADD	Homo sapiens	Q15628	CoIP	11684708
Intra	KRT18	P05783	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	35271311
Intra	KRT18	P05783	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	KRT18	P05783	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	KRT18	P05783	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	KRT18	P05783	MACROD1	Homo sapiens	Q9BQ69	Anti Bait CoIP	20035625
Intra	KRT18	P05783	MACROD1	Homo sapiens	Q9BQ69	Anti Tag CoIP	20035625
Intra	KRT18	P05783	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25910212
Intra	KRT18	P05783	GOLGA2	Homo sapiens	Q08379	Y2H Bait-Prey Pool	25910212
Intra	KRT18	P05783	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	KRT18	P05783	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	KRT18	P05783	GOLGA2	Homo sapiens	Q08379	Y2H Array	25910212
Intra	KRT18	P05783	SYCE1	Homo sapiens	Q8N0S2	Y2H Array	25910212
Intra	KRT18	P05783	SYCE1	Homo sapiens	Q8N0S2	Y2H Bait-Prey Pool	25910212
Intra	KRT18	P05783	SYCE1	Homo sapiens	Q8N0S2	Validated Y2H	25910212
Intra	KRT18	P05783	KRT81	Homo sapiens	Q14533	Validated Y2H	32296183
Intra	KRT18	P05783	HGS	Homo sapiens	O14964	Y2H Bait-Prey Pool	25910212
Intra	KRT18	P05783	HGS	Homo sapiens	O14964	Validated Y2H	25910212
Intra	KRT18	P05783	HGS	Homo sapiens	O14964	Y2H Pooling	16189514
Intra	KRT18	P05783	HGS	Homo sapiens	O14964	Y2H Array	25910212
Intra	KRT18	P05783	EFHC1	Homo sapiens	Q5JVL4	Validated Y2H	32296183
Intra	KRT18	P05783	NME7	Homo sapiens	Q9Y5B8	Y2H Pooling	16189514
Intra	KRT18	P05783	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	KRT18	P05783	TEKT4	Homo sapiens	Q8WW24	Validated Y2H	32296183
Intra	KRT18	P05783	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	21988832
Intra	KRT18	P05783	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	KRT18	P05783	PKP1	Homo sapiens	Q13835-2	Solution Sedimentation	10852826
Intra	KRT18	P05783	PKP1	Homo sapiens	Q13835-2	Far-WB	10852826
Cross	KRT18	P05783	tir	Escherichia coli O127:H6	B7UM99	IF	14710194

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KRT18 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P71668	KRT18 Protein, Human (HEK293, His)	P05783 (S2-H430)	≥ 90%, as determined by reducing SDS-PAGE.

KRT18 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81181	Cytokeratin 18 Antibody	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat
HY-P83963	Cytokeratin 18 Antibody (YA3660)	WB, IHC-P, ELISA	Human
HY-P83963A	Cytokeratin 18 Antibody (YA3660)(PBS only)	WB, IHC-P, ELISA	Human
HY-P83964	Cytokeratin 18 Antibody (YA3661)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P83964A	Cytokeratin 18 Antibody (YA3661)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P85904	Cytokeratin 8/18 Antibody (YA5596)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86058	Cytokeratin 8/18 Antibody (YA5750)	IHC-P, ELISA	Human, Mouse, Rat
HY-P86497	Cytokeratin 18 Antibody (YA6189)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86723	Cytokeratin 18 Antibody (YA6415)	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue	Human, Mouse, Rat
HY-P86723A	Cytokeratin 18 Antibody (YA6415)(PBS only)	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cryptogenic Cirrhosis	Cirrhosis, Cryptogenic Cirrhosis, Cryptogenic, Susceptibility To
Cirrhosis, Familial
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Alcoholic Hepatitis	Acute Alcoholic Hepatitis Acute Alcoholic Liver Disease Hepatitis, Alcoholic Hepatitis Alcoholic Ah - [Alcoholic Hepatitis] Ethanol Hepatitis
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Ameloblastoma	Adenoameloblastoma
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Neuroendocrine Carcinoma	Neuroendocrine Cancer Carcinoma Neuroendocrine Carcinoma, Neuroendocrine
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Autoimmune Hepatitis	Aih Hepatitis, Autoimmune Autoimmune Chronic Active Hepatitis Autoimmune Hepatitis With Centrilobular Necrosis Autoimmune Chronic Hepatitis Hepatitis Autoimmune
Oncocytoma	Oxyphilic Adenoma Follicular Adenoma, Oxyphilic Cell Adenoma, Oxyphilic Hurthle Cell Tumor Oncocytic Neoplasm
Viral Hepatitis	Animal Viral Hepatitis Hepatitis, Viral, Animal Human Viral Hepatitis Viral Hepatitis With Hepatic Coma
Myoepithelioma	Benign Myoepithelioma Myoepithelial Adenoma Myoepithelial Neoplasm Malignant Myoepithelioma
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Epithelioid Trophoblastic Tumor	Trophoblastic Tumor, Epithelioid
Odontoma
Cholecystitis	Acute Cholecystitis Chronic Cholecystitis Acalculous Cholecystitis Acute And Chronic Cholecystitis Acute On Chronic Cholecystitis Gallstone Cholecystitis Cholecystitis, Acute Calculus Of Gallbladder With Cholecystitis Gallbladder Inflammation Acute Cholecystitis Infection Acute Acalculous Cholecystitis Chronic Acalculous Cholecystitis Nonfunctioning Gallbladder
Lung Clear Cell Carcinoma
Fatty Liver Disease	Alcoholic Fatty Liver Fatty Liver Fatty Liver, Alcoholic Fatty Change Of Liver Hepatic Lipidosis Steatosis Of Liver Fatty Liver Alcoholic Steatohepatitis Etoh Fatty Liver Etoh Fatty Liver Metamorphosis Fatty Etoh Liver Necrosis
Gallbladder Sarcoma	Malignant Mesenchymal Tumor Of Gallbladder
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Mucoepidermoid Carcinoma	Mec Salivary Gland Mucoepidermoid Carcinoma C3772 Carcinoma Mucoepidermoid Carcinoma, Mucoepidermoid
Cervical Clear Cell Adenocarcinoma	Clear Cell Carcinoma Of The Cervix Uteri
Teratoma	Teratomas
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hepatoblastoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Skin Carcinoma	Skin Cancer Carcinoma Of Skin Ca - Skin Cancer Cancer Of Skin Malignant Neoplasm Of Skin Melanoma And Non-Melanoma Skin Cancer Skin Cancers Cancer, Skin
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Placental Site Trophoblastic Tumor	Trophoblastic Tumor Placental Site Trophoblastic Tumor, Placental Site Placental Site Trophoblastic Tumour Placental-Site Gestational Trophoblastic Neoplasm Placenta Neoplasm Psst Deciduoma Placental Cancer Primary Malignant Neoplasm Of Placenta
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Thymic Carcinoma	Malignant Thymoma Thymoma, Malignant
Mucinous Tubular And Spindle Renal Cell Carcinoma	Mucinous Tubular And Spindle Cell Renal Carcinoma
Angiosarcoma	Hemangiosarcoma
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Breast Ductal Carcinoma	Ductal Breast Carcinoma Duct Carcinoma Carcinoma, Ductal Mammary Ductal Carcinoma Ductal Carcinoma
Craniopharyngioma	Neoplasm Of Rathke'S Pouch Adamantinomatous Tumor Craniopharyngeal Duct Tumor Dysodontogenic Epithelial Tumor Rathke'S Pouch Tumor
Hidrocystoma	Apocrine Cystadenoma Eccrine Hidrocystoma Eccrine Cystadenoma Eccrine Hidrocystoma Of Skin Apocrine Adenoma
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Intrahepatic Gall Duct Cancer	Malignant Neoplasm Of Intrahepatic Bile Ducts Malignant Neoplasm Of Intrahepatic Gall Duct Ca Intrahepatic Bile Ducts Malignant Neoplasm Of Intrahepatic Biliary Passages Intrahepatic Bile Duct Carcinoma
Hepatoid Adenocarcinoma
Non-Alcoholic Steatohepatitis	Nonalcoholic Steatohepatitis Nash Nash - [Non-Alcoholic Steatohepatitis] Non-Alcoholic Steatohepatosis
Apocrine Sweat Gland Neoplasm	Apocrine Tumor Apocrine Neoplasm
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Bile Duct Cystadenoma	Cystadenoma Of The Bile Duct
Squamous Cell Bile Duct Carcinoma	Bile Duct Squamous Cell Carcinoma
Small Cell Cancer Of The Lung	Small Cell Lung Cancer Small Cell Lung Carcinoma Sclc Small-Cell Cancer Of Lung Lung Small Cell Carcinoma Sclc1 Sccl Cancer, Lung, Small Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Vulvar Proximal-Type Epithelioid Sarcoma
Central Epithelioid Sarcoma	Proximal-Type Epithelioid Sarcoma
Immunodeficiency 58	IMD58 Severe Combined Immunodeficiency Due To Carmil2 Deficiency Combined Immunodeficiency Due To Carmil2 Deficiency Combined Immunodeficiency Due To Rltpr Deficiency
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Esophageal Adenosquamous Carcinoma
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Crigler-Najjar Syndrome, Type I	Crigler-Najjar Syndrome Crigler-Najjar Syndrome Type 1 Bilirubin Udp Glucuronyl Transferase Deficiency Crigler Najjar Syndrome Crigler Najjar Syndrome, Type 1 Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Bilirubin-Ugt Deficiency Hyperbilirubinemia, Crigler-Najjar Type I Hblrcn1 Familial Nonhemolytic Unconjugated Hyperbilirubinemia Hereditary Unconjugated Hyperbilirubinemia Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1 Bilirubin-Ugt Deficiency Type 1 Crigler-Najjar Syndrome 1 CN1 Cn-I Crigler-Najjar Syndrome Type I Hereditary Unconjugated Hyperbilirubinaemia Ugt Deficiency Bilirubin Glucuronosyltransferase Deficiency Crigler-Najjar Disease Or Syndrome Deficiency Of Glucuronosyltransferase Glucuronyl Transferase Deficiency Glucuronyltransferase Deficiency Udp Glucuronyl Transferase Deficiency Cns - [Crigler-Najjar Syndrome] Congenital Familial Nonhemolytic Jaundice
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Diabetes Mellitus	Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS07441	KRT18 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19704	Krt18 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26199	Krt18 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KRT18	VGNC	VGNC:30719
Mus musculus	KRT18	MGD	MGI:96692
Canis familiaris	KRT18	VGNC	VGNC:106506
Felis catus	KRT18	VGNC	VGNC:84049
Rattus norvegicus	KRT18	RGD	RGD:619935
Others	KRT18	NCBI