CDC37L1 - cell division cycle 37 like 1, HSP90 cochaperone Gene

Also Known as HARC; CDC37B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55664

About CDC37L1

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:4,679,569-4,708,399 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 13.5), heart (RPKM 8.3) and 25 other tissues.

Summary

CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several Other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008]

CDC37L1 Products (1)

mRNA Protein Name
NM_017913.4 NP_060383.2 hsp90 co-chaperone Cdc37-like 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC37L1 Protein Structure

CDC37_M

CDC37_M: Cdc37 Hsp90 binding domain (132 - 282)

  • 0
  • 100
  • 200
  • 300
  • 337 a.a.
Protein Preferred Names Protein Names

hsp90 co-chaperone Cdc37-like 1

  • CDC37 cell division cycle 37 homolog-like 1

CDC37L1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
CDC37L1 Q7L3B6 STIP1 Homo sapiens P31948
Anti Tag CoIP
25036637
Intra
CDC37L1 Q7L3B6 HSP90AA1 Homo sapiens P07900
Lumier
25036637
Intra
CDC37L1 Q7L3B6 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
25036637
Intra
CDC37L1 Q7L3B6 HSP90AB1 Homo sapiens P08238
Y2H Array
25416956
Intra
CDC37L1 Q7L3B6 HSP90AB1 Homo sapiens Q6PK50
Lumier
25036637
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Delusional Disorder

  • Persistent Delusional Disorders

  • Delusional Perception

  • Induced Delusional Disorder
Ulceroglandular Tularemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-111414 Hsp90-Cdc37-IN-1 Inhibitor 99.66% Unkown
HY-RS02298 CDC37L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CDC37L1 VGNC VGNC:27067
Macaca mulatta CDC37L1 VGNC VGNC:70790
Rattus norvegicus CDC37L1 RGD RGD:1309295
Canis familiaris CDC37L1 VGNC VGNC:38995
Mus musculus CDC37L1 MGD MGI:1914322
Felis catus CDC37L1 VGNC VGNC:60655
Others CDC37L1 NCBI