PSMA2 - proteasome 20S subunit alpha 2 Gene

Also Known as MU; HC3; PSC2; PMSA2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5683

About PSMA2

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:42,916,861-42,932,174 (from NCBI)

This gene has 10 transcripts (splice variants), 282 orthologues and 18 paralogues. Ubiquitous expression in liver (RPKM 64.0), fat (RPKM 48.4) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008]

PSMA2 Products (1)

mRNA	Protein	Name
NM_002787.5	NP_002778.1	proteasome subunit alpha type-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12376572	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in response to virus	IEP IEP: Inferred from expression pattern	16548883	GOA

Cellular Component GO Annotation	Evidence	Références	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	34711951	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	34711951	GOA
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA
part of proteasome core complex	IDA IDA: Inferred from direct assay	34711951	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMA2 Protein Structure

Proteasome_A_N

Proteasome

0
100
200
234 a.a.

Protein Preferred Names	Protein Names
proteasome subunit alpha type-2	macropain subunit C3

PSMA2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Cross	PSMA2	P25787	ORF9b	Human SARS coronavirus	Q6S8E0	Lumier	22046132
Cross	PSMA2	P25787	ORF9b	Human SARS coronavirus	Q6S8E0	Y2H Pooling	22046132
Intra	PSMA2	P25787	PSMA3	Homo sapiens	P25788	Anti Tag CoIP	33961781
Intra	PSMA2	P25787	PSMA3	Homo sapiens	P25788	Anti Bait CoIP	12376572
Intra	PSMA2	P25787	PSMA6	Homo sapiens	P60900	Y2H	14733938
Intra	PSMA2	P25787	PSMA6	Homo sapiens	P60900	Anti Bait CoIP	15887188
Intra	PSMA2	P25787	PSMA6	Homo sapiens	P60900	Anti Bait CoIP	12376572
Intra	PSMA2	P25787	PSMA6	Homo sapiens	P60900	Anti Tag CoIP	33961781
Intra	PSMA2	P25787	PSMA4	Homo sapiens	P25789	Anti Bait CoIP	12376572
Intra	PSMA2	P25787	PSMA4	Homo sapiens	P25789	Pull Down	15225636
Intra	PSMA2	P25787	PSMA4	Homo sapiens	P25789	Anti Bait CoIP	15887188
Intra	PSMA2	P25787	PSMA4	Homo sapiens	P25789	Anti Tag CoIP	33961781
Intra	PSMA2	P25787	PSMA4	Homo sapiens	P25789	Y2H	14733938
Intra	PSMA2	P25787	PSMA1	Homo sapiens	P25786	Y2H	21988832
Intra	PSMA2	P25787	PSMA1	Homo sapiens	P25786	Anti Tag CoIP	33961781
Intra	PSMA2	P25787	PSMA1	Homo sapiens	P25786	Anti Bait CoIP	12376572
Intra	PSMA2	P25787	PSMA7	Homo sapiens	O14818	Pull Down	15225636
Intra	PSMA2	P25787	PSMA7	Homo sapiens	O14818	Anti Tag CoIP	33961781
Intra	PSMA2	P25787	PSMA7	Homo sapiens	O14818	Anti Bait CoIP	12376572
Intra	PSMA2	P25787	PSMA7	Homo sapiens	O14818	Y2H	15225636

Cross: Cross-species interaction Intra: Intraspecies interaction

PSMA2 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81999	Proteasome 20S alpha 2/HC3 Antibody (YA1744)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P81999A	Proteasome 20S alpha 2/HC3 Antibody (YA1744)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P82639	Proteasome 20S alpha 2/HC3 Antibody (YA2384)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P11485	JR11-PEG3-HBED-CC-PSMA-03		/	Unkown
HY-P11488	JR11-PEG3-DOTA-PSMA-03	Ligand	/	Unkown
HY-RS11292	PSMA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PSMA2	VGNC	VGNC:55751
Rattus norvegicus	PSMA2	RGD	RGD:61842
Macaca mulatta	PSMA2	VGNC	VGNC:108431
Mus musculus	PSMA2	MGD	MGI:104885
Others	PSMA2	NCBI