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MTA3 - metastasis associated 1 family member 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57504

About MTA3

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:42,494,110-42,756,946 (from NCBI)

This gene has 19 transcripts (splice variants), 209 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 6.3), ovary (RPKM 5.7) and 24 other tissues.

Summary

Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated. Located in nucleoplasm. Part of NuRD complex. [provided by Alliance of Genome Resources, Apr 2022]

MTA3 Products (6)

mRNA	Protein	Name
NM_001282755.2	NP_001269684.1	metastasis-associated protein MTA3 isoform a
NM_001282756.2	NP_001269685.1	metastasis-associated protein MTA3 isoform a
NM_001330442.2	NP_001317371.1	metastasis-associated protein MTA3 isoform c
NM_001330443.2	NP_001317372.1	metastasis-associated protein MTA3 isoform d
NM_001330444.2	NP_001317373.1	metastasis-associated protein MTA3 isoform e
NM_020744.4	NP_065795.1	metastasis-associated protein MTA3 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22926524	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	9790534	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15454082	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of NuRD complex	IDA IDA: Inferred from direct assay	22926524	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28977666	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTA3 Protein Structure

BAH

ELM2

GATA

0
100
200
300
400
500
594 a.a.

Protein Preferred Names	Protein Names
metastasis-associated protein MTA3	metastasis associated gene family, member 3

MTA3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	MTA3	Q9BTC8	GATA3	Homo sapiens	P23771	Anti Bait CoIP	26028330
Intra	MTA3	Q9BTC8	GATA3	Homo sapiens	P23771	Anti Tag CoIP	26028330
Intra	MTA3	Q9BTC8	GATA3	Homo sapiens	P23771	CH-IP	26028330
Intra	MTA3	Q9BTC8	EHMT2	Homo sapiens	Q96KQ7	Anti Tag CoIP	26028330
Intra	MTA3	Q9BTC8	EHMT2	Homo sapiens	Q96KQ7	Pull Down	26028330
Intra	MTA3	Q9BTC8	EHMT2	Homo sapiens	Q96KQ7	Anti Bait CoIP	26028330
Intra	MTA3	Q9BTC8	EHMT2	Homo sapiens	Q96KQ7	CH-IP	26028330

Cross: Cross-species interaction Intra: Intraspecies interaction

MTA3 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P89655	MTA3 Antibody (YA8999)	WB, IP	human

Related Diseases

Diseases	Alias
Pyloric Stenosis
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson Gilford Progeria Syndrome Hutchinson-Gilford Disease Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Hypertrophic Pyloric Stenosis	Congenital Hypertrophic Pyloric Stenosis Pyloric Stenosis, Hypertrophic Congenital Or Infantile Stricture Of Pylorus Achalasia Of The Pylorus Congenital Hypertrophy Of The Pylorus Infantile Hypertrophy Of The Pylorus Infantile Constriction Of The Pylorus Congenital Stenosis Of The Pylorus Congenital Constriction Of The Pylorus Congenital Stricture Of The Pylorus Infantile Hypertrophic Pyloric Stenosis Infantile Stenosis Of The Pylorus Infantile Stricture Of The Pylorus Congenital Or Infantile Constriction Of Pylorus Infantile Pyloric Obstruction Infantile Pyloric Hypertrophy Pylorus Achalasia Pyloric Constriction Infantile Pyloric Stricture Infantile Pyloric Stenosis Congenital Spasm Of Pylorus Congenital Pylorospasm Congenital Pyloric Stricture Congenital Pyloric Spasm Congenital Or Infantile Spasm Of Pylorus Congenital Or Infantile Obstruction Of Pylorus Congenital Pyloric Stenosis
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS08748	MTA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MTA3	VGNC	VGNC:31715
Macaca mulatta	MTA3	VGNC	VGNC:74814
Felis catus	MTA3	VGNC	VGNC:63640
Rattus norvegicus	MTA3	RGD	RGD:1306803
Mus musculus	MTA3	MGD	MGI:2151172
Others	MTA3	NCBI