ABTB1 - ankyrin repeat and BTB domain containing 1 Gene

Also Known as BPOZ; BTB3; BTBD21; EF1ABP; PP2259

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80325

About ABTB1

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:127,672,952-127,680,926 (from NCBI)

This gene has 15 transcripts (splice variants), 185 orthologues and 11 paralogues. Ubiquitous expression in spleen (RPKM 23.0), bone marrow (RPKM 13.1) and 25 other tissues.

Summary

This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the Phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants. [provided by RefSeq, Mar 2010]

ABTB1 Products (2)

mRNA Protein Name
NM_032548.4 NP_115937.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 1
NM_172027.3 NP_742024.1 ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
21145461 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABTB1 Protein Structure

Ank_5

Ank_5: Ankyrin repeats (many copies) (21 - 74)

BTB

BTB: BTB/POZ domain (105 - 208)

BTB

BTB: BTB/POZ domain (271 - 374)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 478 a.a.
Protein Preferred Names Protein Names

ankyrin repeat and BTB/POZ domain-containing protein 1

  • ankyrin repeat and BTB (POZ) domain containing 1

ABTB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
ABTB1 Q969K4 ZBTB21 Homo sapiens Q9ULJ3
Anti Tag CoIP
33961781
Intra
ABTB1 Q969K4 ZBTB21 Homo sapiens Q9ULJ3
Anti Tag CoIP
28514442
Intra
ABTB1 Q969K4 EEF1A2 Homo sapiens Q05639
Y2H Prey Pooling
32296183
Intra
ABTB1 Q969K4 EEF1A2 Homo sapiens Q05639
Y2H Array
32296183
Intra
ABTB1 Q969K4 EEF1A2 Homo sapiens Q05639
Y2H Prey Pooling
25416956
Intra
ABTB1 Q969K4 EEF1A2 Homo sapiens Q05639
Anti Tag CoIP
33961781
Intra
ABTB1 Q969K4 EEF1A2 Homo sapiens Q05639
Anti Tag CoIP
28514442
Intra
ABTB1 Q969K4 EEF1D Homo sapiens P29692
Anti Tag CoIP
33961781
Intra
ABTB1 Q969K4 CUL3 Homo sapiens Q13618
Validated Y2H
25416956
Intra
ABTB1 Q969K4 EEF1D Homo sapiens P29692-2
Y2H Array
32296183
Intra
ABTB1 Q969K4 EEF1D Homo sapiens P29692-2
Anti Tag CoIP
28514442
Intra
ABTB1 Q969K4 EEF1D Homo sapiens P29692-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS00115 ABTB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ABTB1 RGD RGD:1359363
Mus musculus ABTB1 MGD MGI:1933148
Felis catus ABTB1 VGNC VGNC:59494
Macaca mulatta ABTB1 VGNC VGNC:69459
Bos taurus ABTB1 VGNC VGNC:25515
Canis familiaris ABTB1 VGNC VGNC:37486
Others ABTB1 NCBI