YEATS4 - YEATS domain containing 4 Gene

Also Known as YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8089

About YEATS4

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:69,359,743-69,462,793 (from NCBI)

This gene has 5 transcripts (splice variants) and 207 orthologues. Broad expression in testis (RPKM 7.3), bone marrow (RPKM 4.6) and 25 other tissues.

Summary

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

YEATS4 Products (2)

mRNA Protein Name
NM_001300950.2 NP_001287879.1 YEATS domain-containing protein 4 isoform 2
NM_006530.4 NP_006521.1 YEATS domain-containing protein 4 isoform 1

YEATS4 Protein Structure

YEATS

YEATS: YEATS family (44 - 124)

  • 0
  • 100
  • 200
  • 227 a.a.
Protein Preferred Names Protein Names

YEATS domain-containing protein 4

  • NuMA binding protein 1

YEATS4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
YEATS4 O95619 TPM1 Homo sapiens P09493-10
Validated Y2H
32296183
Intra
YEATS4 O95619 ANKK1 Homo sapiens Q8NFD2
Validated Y2H
32296183
Intra
YEATS4 O95619 TACC1 Homo sapiens O75410
Y2H
11903063
Intra
YEATS4 O95619 TACC1 Homo sapiens O75410
Anti Bait CoIP
11903063
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Glioma
Well-Differentiated Liposarcoma

  • Atypical Lipomatous Tumor

  • Atypical Lipoma

  • Alt

  • Wdls

  • Liposarcoma, Well Differentiated

  • Pleomorphic Lipoma
Macular Dystrophy, Patterned, 3

  • Martinique Crinkled Retinal Pigment Epitheliopathy

  • Patterned Macular Dystrophy 3

  • MDPT3

  • Mcrpe
Pleomorphic Liposarcoma

  • Pls

  • Liposarcoma Pleomorphic

  • Liposarcoma, Pleomorphic
Cellular Myxoid Liposarcoma

  • Round Cell Liposarcoma
Dedifferentiated Liposarcoma

  • Ddls

  • Liposarcoma Dedifferentiated

  • Liposarcoma, Dedifferentiated
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-155412 PFI-6 99.91% Unkown
HY-152242 YEATS4-IN-1 / Unkown
HY-RS15921 YEATS4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18315 Yeats4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24793 Yeats4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus YEATS4 MGD MGI:1927224
Felis catus YEATS4 VGNC VGNC:67135
Canis familiaris YEATS4 VGNC VGNC:48483
Rattus norvegicus YEATS4 RGD RGD:1305741
Bos taurus YEATS4 VGNC VGNC:37021
Others YEATS4 NCBI