UBL4A - ubiquitin like 4A Gene

Also Known as GDX; G6PD; GET5; MDY2; UBL4; TMA24; DX254E; DXS254E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8266

About UBL4A

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,483,717-154,486,615 (from NCBI)

This gene has 7 transcripts (splice variants), 178 orthologues and 10 paralogues. Ubiquitous expression in heart (RPKM 16.9), brain (RPKM 12.9) and 25 other tissues.

Summary

Enables chaperone binding activity. Involved in tail-anchored membrane protein insertion into ER membrane. Located in cytosol; membrane; and nucleoplasm. Part of BAT3 complex. [provided by Alliance of Genome Resources, Apr 2022]

UBL4A Products (1)

mRNA Protein Name
NM_014235.5 NP_055050.1 ubiquitin-like protein 4A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
19615732 GOA
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
25535373 GOA
Biological Process GO Annotation Evidence Références Source
involved in post-translational protein targeting to endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
25535373 GOA
involved in regulation of protein stability IDA
IDA: Inferred from direct assay
21636303 GOA
involved in tail-anchored membrane protein insertion into ER membrane IDA
IDA: Inferred from direct assay
25535373 GOA
involved in tail-anchored membrane protein insertion into ER membrane IMP
IMP: Inferred from mutant phenotype
20676083 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
20676083 GOA
Cellular Component GO Annotation Evidence Références Source
part of BAT3 complex IDA
IDA: Inferred from direct assay
20676083 GOA
part of BAT3 complex IPI
IPI: Inferred from physical interaction
25535373 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21636303 GOA
located in cytosol IDA
IDA: Inferred from direct assay
20676083 GOA
located in membrane IDA
IDA: Inferred from direct assay
23246001 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21636303 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBL4A Protein Structure

ubiquitin

ubiquitin: Ubiquitin family (6 - 73)

  • 0
  • 100
  • 157 a.a.
Protein Preferred Names Protein Names

ubiquitin-like protein 4A

  • ubiquitin-like 4

UBL4A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
UBL4A P11441 PER2 Homo sapiens O15055
Y2H Prey Pooling
32296183
Intra
UBL4A P11441 PER2 Homo sapiens O15055
Y2H Array
32296183
Intra
UBL4A P11441 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra
UBL4A P11441 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra
UBL4A P11441 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra
UBL4A P11441 CHAT Homo sapiens P28329-3
Validated Y2H
32814053
Intra
UBL4A P11441 CHAT Homo sapiens P28329-3
Y2H Array
32814053
Intra
UBL4A P11441 CHAT Homo sapiens P28329-3
Y2H Pooling
32814053
Intra
UBL4A P11441 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra
UBL4A P11441 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
UBL4A P11441 SGTA Homo sapiens O43765
Anti Tag CoIP
19615732
Intra
UBL4A P11441 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
UBL4A P11441 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
UBL4A P11441 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
UBL4A P11441 TRAF4 Homo sapiens Q9BUZ4
Validated Y2H
32296183
Intra
UBL4A P11441 CDCA7L Homo sapiens Q96GN5
Y2H Prey Pooling
25416956
Intra
UBL4A P11441 CDCA7L Homo sapiens Q96GN5
Y2H Array
25416956
Intra
UBL4A P11441 CDCA7L Homo sapiens Q96GN5
Validated Y2H
25416956
Intra
UBL4A P11441 S100P Homo sapiens P25815
Y2H Array
32296183
Intra
UBL4A P11441 S100P Homo sapiens P25815
Validated Y2H
32296183
Intra
UBL4A P11441 S100P Homo sapiens P25815
Y2H Prey Pooling
32296183
Intra
UBL4A P11441 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
UBL4A P11441 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra
UBL4A P11441 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
UBL4A P11441 ERP27 Homo sapiens Q96DN0
Validated Y2H
32296183
Intra
UBL4A P11441 ERP27 Homo sapiens Q96DN0
Y2H Array
32296183
Intra
UBL4A P11441 ERP27 Homo sapiens Q96DN0
Y2H Prey Pooling
32296183
Cross
UBL4A P11441 vif Human immunodeficiency virus P12504
Pull Down
22190034
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS15375 UBL4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22893 Ubl4a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UBL4A VGNC VGNC:78702
Felis catus UBL4A VGNC VGNC:66774
Mus musculus UBL4A MGD MGI:95049
Rattus norvegicus UBL4A RGD RGD:1563983
Canis familiaris UBL4A VGNC VGNC:48077
Others UBL4A NCBI