HDAC6-IN-73
HDAC6-IN-73 is a highly potent and selective HDAC6 inhibitor with an IC50 of 0.007 μM ± 0.001, ~1771-fold selectivity over HDAC1, ~131-fold selectivity over HDAC8, and antiproliferative activity in hematological cancer cell lines.HDAC6-IN-73 can be used for the research of hematological malignancies.
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- Formule: C23H28N2O5
- Masse moléculaire:412.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
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HDAC6 7 nM (IC50) |
HDAC1 12.4 μM (IC50) |
HDAC8 0.92 μM (IC50) |
In Vitro
HDAC6-IN-73 (compound 7c) significantly inhibits the proliferation of Jurkat, Namalwa, and K-562 cells[1].
HDAC6-IN-73 exhibits micromolar cytotoxicity against hematological cancer cell lines, and shows stronger activity against malignant cells compared to some normal cells[1].
HDAC6-IN-73 (50 μM; 48 h) induces significant late and early apoptosis in Namalwa cells and causes accumulation of Namalwa cells at the sub-G1 phase; no obvious cell cycle changes are observed in Jurkat or K-562 cells[1].
HDAC6-IN-73 (50 μM; 24 h) induces significant α-tubulin acetylation in Jurkat and Namalwa cells, with minimal effects on histone H3 acetylation; no α-tubulin acetylation is detected in K-562 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat, Namalwa, and K-562 cells; HS-5, CCD-18Co, HaCaT cells
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Concentration:IC50 assay
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Incubation Time:72 h
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Result:Exhibited the strongest antiproliferative effects against Jurkat, Namalwa, and K-562 cells with IC50 of 3.7 μM, 7.7 μM, 18 μM; as well as inhibiting HS-5, CCD-18Co, HaCaT cells with 9.3 μM, 33 μM, and 10.3 μM.
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Cell Line:Jurkat, Namalwa, and K-562 cells
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Concentration:50 μM
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Incubation Time:48 h
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Result:Induced significant late and early apoptosis in Namalwa cells, with apoptosis rates at 50 μM exceeding those of reference compounds.
Promoted accumulation of cells in the sub-G1 phase in Namalwa cells; showed no significant cell cycle changes in Jurkat or K-562 cells.
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Cell Line:Jurkat, Namalwa, and K-562 cells
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Concentration:50 μM
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Incubation Time:24 h
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Result:Induced marked acetylation of α-tubulin with minimal effect on histone H3 acetylation in Jurkat and Namalwa cells; showed no detectable α-tubulin acetylation in K-562 cells.
Chemical Information
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Masse moléculaire 412.48
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Formule C23H28N2O5
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SMILES
CCCCCCC(N(CC1=CC=C(C(NO)=O)C=C1)CC2=CC(OCO3)=C3C=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-73 Related Classifications
HY-181577 Related Classifications
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