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Icrucumab

(Synonyms: Anti-VEGFR1/FLT1 Reference Antibody; IMC-18F1)
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Icrucumab (Anti-VEGFR1/FLT1 Reference Antibody; IMC-18F1) is an IgG1 antibody inhibitor targeting VEGFR-1/FLT1 with anti-tumor activity. By blocking ligand-dependent phosphorylation and downstream signal transduction, Icrucumab reduces the activities of MAPK and Akt in breast cancer xenograft models, inhibits the proliferation and invasion of VEGFR-1-positive tumor cells, and reverses the conversion of M1 macrophages to the pro-tumor M2-like phenotype. Icrucumab also inhibits tumor cell proliferation, promotes apoptosis, and effectively suppresses tumor growth through direct targeting of tumors and host support mechanisms. In addition, Icrucumab exhibits a synergistic effect when combined with chemotherapeutic agents, and it is used in research related to various cancers including advanced solid malignancies, thyroid cancer, melanoma, and lung cancer.

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  • Pureté: 99.9%
  • CAS No.: 1024603-92-6
  • Masse moléculaire:146.68 kDa
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Icrucumab
  • Experimental Validation Results for Icrucumab
  • Experimental Validation Results for Icrucumab
  • Icrucumab Chemical Structure
    Icrucumab Chemical Structure
CAS No.: 1024603-92-6
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized VEGFR-1 Protein, Human (328a.a, HEK293, His, HY-P73065) can bind Icrucumab. The EC50 for this effect is 5.461 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 HUVEC cells with Icrucumab (HY-P99364, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Icrucumab Chemical Structure
    1/16
  • Icrucumab
  • Immobilized VEGFR-1 Protein, Human (328a.a, HEK293, His, HY-P73065) can bind Icrucumab. The EC50 for this effect is 5.461 ng/mL.
  • Flow cytometric analysis of 1X106 HUVEC cells with Icrucumab (HY-P99364, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).